Effect of Oliceridine on Rebound Pain

Arthroscopic Knee Surgery Clinical Trial

Official title:

A Clinical Study on the Effect of Oliceridine（TRV130） on Postoperative Rebound Pain and Early Rehabilitation Exercise After Knee Arthroscopy

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06382896
• Other study ID #: FirstAHXiamenU-YB-2
• Status: Recruiting
• Start date: January 1, 2024
• Est. completion date: December 31, 2025

Study information

• Verified date: April 2024
• Source: The First Affiliated Hospital of Xiamen University
• Contact: Bin Yang, doctor
• Phone: 13859986036
• Email: yangbin4332[@]outlook.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this clinical study was to identify the risk factors for postoperative pain outburst in patients undergoing arthroscopic knee surgery after Oliceridine and nerve block, and to evaluate the effect of oxeridine on early rehabilitation exercise in patients. A total of 320 patients undergoing arthroscopic knee arthroscopy under general anesthesia combined with femoral nerve block were selected to record the time and duration of postoperative pain outbreak, pain degree, age, gender, operation type, previous surgical history and other related risk factors.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 320
• Est. completion date: December 31, 2025
• Est. primary completion date: December 31, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

1. Age 18-70 years old;2. Body mass index (BMI) 18-30kg /m2;3. American Society of Anesthesiologists (ASA) Grade I to II;4. Hospital stay >24h.

Exclusion Criteria:

1. Patients who cannot understand the numerical rating scale score and give feedback;2. Known allergy to the drug in the study;3. Infection of puncture site with nerve block;4. Oral analgesics for more than 2 weeks before surgery;5. Long-term use of glucocorticoids;6. Simultaneous surgery on both limbs;7. A psychopath;8. Severe compound trauma;9. Pregnant and lactating women.

Related Conditions & MeSH terms

• Arthroscopic Knee Surgery
• Rebound Pain

Intervention

Other:
• No intervention
This was an observational study

Locations

Country	Name	City	State
China	First Affiliated Hospital of Xiamen University	Xiamen	Fujian

Sponsors (1)

Lead Sponsor	Collaborator
The First Affiliated Hospital of Xiamen University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Time of onset of postoperative rebound pain	The numerical rating scale was used	Within 48 hours after surgery
Primary	The duration of the rebound pain	The numerical rating scale was used	Within 48 hours after surgery
Primary	The degree of the rebound pain	The numerical rating scale was used	Within 48 hours after surgery
Primary	age	Fill in the postoperative questionnaire	Within 48 hours after surgery
Primary	sex	Fill in the postoperative questionnaire	Within 48 hours after surgery
Primary	Surgical procedure	Fill in the postoperative questionnaire	Within 48 hours after surgery
Primary	Previous surgical history	Fill in the postoperative questionnaire	Within 48 hours after surgery
Secondary	Movement recovery time	Fill in the postoperative questionnaire	Within 7 days of surgery