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Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Lower Extremity Operations

Arthroplasty, Replacement Clinical Trial

Official title:
Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Unilateral Total Knee Replacement - a Randomized, Controlled Trial

Clinical Trial Summary

Ischemia reperfusion injury causes the release of free oxygen radicals. The selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during ischemic injury. The aim of this study is to evaluate the effect of dexmedetomidine on inflammatory responses during ischemia-reperfusion injury in skeletal muscle.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02648958
Study type Interventional
Source Yonsei University
Contact
Status Completed
Phase N/A
Start date January 2016
Completion date July 31, 2017
View Details
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