Arthroplasty, Replacement, Hip Clinical Trial
— KETAMINEOfficial title:
Impact of the Route of Administration of Ketamine Associated With Morphine PCA on Analgesia After Total Hip Arthroplasty
Verified date | April 2013 |
Source | Assistance Publique - Hôpitaux de Paris |
Contact | n/a |
Is FDA regulated | No |
Health authority | France: Ministry of Health |
Study type | Interventional |
Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid
Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that
ketamine administrated separately via a continuous infusion, could induced a better
analgesic effect.
We will perform a randomised double blind study to determine the best infusion mode of
intravenous ketamine, associated with morphine in PCA syringe or alone in continuous
infusion.
Status | Completed |
Enrollment | 18 |
Est. completion date | October 2010 |
Est. primary completion date | October 2010 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - total hip arthroplasty Exclusion Criteria: - pre operative opioid administration |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
France | Service d'anesthesie-reanimation - Hôpital Bicêtre | Le Kremlin Bicêtre |
Lead Sponsor | Collaborator |
---|---|
Assistance Publique - Hôpitaux de Paris |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Morphine consumption in PACU and in hospitalisation room | at 24 and 48 hours | No | |
Secondary | Postoperative Visual Analogic Score of pain | in Recovery Room, at 24 and 48 hours, in the ward | No | |
Secondary | Postoperative Measure of mechanical hyperalgesia by Von Frey filament device | 24 and 48 hours in the ward | No | |
Secondary | Postoperative measure Ketamine and Nor-Ketamine blood levels | at 24 and 48 hours in the ward | No |
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