Arthroplasty, Hip Replacement Clinical Trial
Official title:
Efficacy of Surgical Skin Preparation Solutions in Hip Arthroplasty Surgery
This study will assess the efficacy of two of the most commonly used surgical skin-preparation solutions: Chloraprep (chlorhexidine-alcohol) and Duraprep (iodine-alcohol) at eliminating bacteria from the hip site by evaluating the residual bacteria present following surgical skin-preparation.
Post-operative infections, although rare, can lead to significant patient morbidity and cost.
A potential risk factor for the development of post-operative wound infection is the amount
of bacterial skin flora present at the operative site at the time of surgery. Therefore, the
use of an effective anti-microbial preoperative skin-preparation solution is essential in
preventing the contamination of the surgical site and in turn the surgical wound.
Several different types of anti-microbial skin preparation solutions are presently used
pre-operatively. However, there is currently no consensus on which solution is superior.
Previous studies have investigated the efficacy of commonly used solutions in the shoulder,
foot and spine, however the bacterial flora from these areas are likely different from the
hip region. Thus the findings in the literature are not necessarily applicable to surgery
involving the hip.
Because of the potentially devastating consequences of a surgical wound infection, ensuring
effective skin preparation prior to surgery is critical. Therefore the identification of a
superior skin-preparation solution for the elimination of bacterial pathogens, specific to
the hip region, could potentially have considerable impact on the clinical care of patients
undergoing hip arthroplasty surgery.
This study will assess the efficacy of two of the most commonly used surgical
skin-preparation solutions: Chloraprep (chlorhexidine-alcohol) and Duraprep (iodine-alcohol),
at eliminating bacteria from the hip site by evaluating the residual bacteria present
following surgical skin-preparation.The primary outcome is as follows: positive culture rates
of residual bacteria following surgical skin preparation. Secondary outcomes that will be
evaluated is culture rates post-surgery (following skin closure) and acute (within 3 months)
post-operative wound complications.
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