Preemptive Analgesia Combination of Celecoxib & Pregabalin in THA

Status Not yet recruiting

Clinical Trial Summary

This is a double-blinded randomized controlled trial aims to evaluate the effect of preemptive analgetic combination of celecoxib and pregabalin to acute pain after total hip arthroplasty. This study will be conducted in Cipto Mangunkusumo Hospital, Jakarta, Indonesia, from October 2022 to April 2023. The subject of this study is adult patient who will be performed total hip arthroplasty.

Clinical Trial Description

1. Research design This is a double-blind, randomized clinical trial which aimed to evaluate the effect of preemptive analgesia combined with Celecoxib and Pregabalin on acute post-THA pain. 2. Study location This study will be conducted at the Cipto Mangunkusumo Hospital, Jakarta, Indonesia. 3. Study time This study will be conducted in October 2022 - April 2023 4. Population and sample The target population of this study is adult patients undergoing THA surgery. The randomization technique used in this study is a simple randomization technique. Researchers randomly determine the allocation of samples without looking at subjects' status in the population. 5. Inclusion criteria - Patients >18 years old - Patients who come to the RSCM Orthopedic Polyclinic - Patients undergoing THA surgery - Patients with Primary and Secondary Pelvic Osteoarthritis - The patient is taking anti-pain and anti-inflammatory drugs regularly 6. Exclusion criteria - Patients with mental disorders - Patients with a history of renal impairment - Pelvic arthritis patients due to rheumatoid arthritis or infection - Patients with diabetes and obesity - Allergy to non-steroidal inflammatory drugs - Asthma history - Coagulation disorders - Patients in the study procedure experienced an incident of severe pain that required another analgesic regimen - History of hypersensitivity to NSAIDs or sulfonamides ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05509946
Study type	Interventional
Source	Indonesia University
Contact	Kemas MA Novriandi, MD
Phone	+628194830011
Email	Azkanovriandi1991@gmail.com
Status	Not yet recruiting
Phase	Phase 2/Phase 3
Start date	October 1, 2022
Completion date	April 30, 2023

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See also
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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Preemptive Analgesia Combination of Celecoxib and Pregabalin in THA

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms