Osteolysis Development Around Uncemented Cups With or Without Screw Holes

Status Completed

Clinical Trial Summary

In order to investigate the role of acetabular cup screw holes for the transport of osteolysis-inducing particles in a total hip arthroplasty articulation, the investigators compare the amount of bone loss around acetabular cups with and without holes. Bone loss is measured with computed tomography at 7 years and 15 - 18 years of follow-up.

Clinical Trial Description

Particles generated by wear and corrosion within an artificial hip articulation can cause biologically mediated bone loss in the surrounding pelvis. Particles can be found within immunologically active cells inside bone lesions. Holes intended for screw fixation in uncemented acetabular cups are believed to be a main route for these particles from the articulation into the pelvic bone. Using pressfit, screws are not always necessary for a successful fixation of an uncemented cup. The investigator's hypothesis is that a pressfit fixated cup without screw holes will display a decreased amount of periacetabular osteolysis compared to a cup with screw holes. Therefore, 95 hips (90 patients) were randomized to receive either pressfit cups without screw holes or the same type of cup with screw holes. The occurence and size of periacetabular osteolysis will be compared between the two groups. In addition, since the patients will have a computed tomography examination at 7 years and between 15 and 18 years the investigator will also analyze development of periacetabular osteolysis over time. The different cups were paired with three different types of femoral stems. Also, articulation wear and cup and stem fixation will be analyzed using radiostereometry. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03692351
Study type	Interventional
Source	Sahlgrenska University Hospital, Sweden
Contact
Status	Completed
Phase	N/A
Start date	June 15, 1994
Completion date	December 31, 2016

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT05181566` - Metal Ion Levels in Total Hip Arthroplasty (THA) With Modular Dual Mobility Cup Compared to Conventional THA	N/A
Completed	`NCT04490304` - The Analysis of Posterior Soft Tissue Repair Durability	N/A
Completed	`NCT05974501` - Pre vs Post Block in Total Knee Arthroplasty (TKA)	Phase 4
Completed	`NCT04565093` - Efficacy of iPACK After Unilateral TKA	N/A
Recruiting	`NCT05845021` - Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty	N/A
Recruiting	`NCT03306810` - Recognition and Treatment of Dysglycemia. AGS - Acute Glucose Service	N/A
Completed	`NCT04289025` - Modelling and AI Using Sensor Data to Personalise REHABilitation Following Joint Replacement	N/A
Not yet recruiting	`NCT06469177` - Patient Centered Post-Op Pain Management Software Tool Interventional Study Verses Standard of Care	N/A
Not yet recruiting	`NCT05014932` - Evaluation of Noise Induced by Ceramic-ceramic Friction Torques of Total Hip Prostheses With Customized Femoral Stem
Active, not recruiting	`NCT04437888` - Intraoperative Ketamine for Patients Undergoing Total Joint Arthroplasty	Early Phase 1
Completed	`NCT05420194` - Assessment of Postural Stability in Patients With Total Knee Arthroplasty
Completed	`NCT03269760` - Multimodal Sleep Pathway for Shoulder Arthroplasty	Phase 1
Completed	`NCT03289247` - Tissue Adhaesive in Wound Closure Following Primary Total Knee Arthroplasty	N/A
Completed	`NCT04433962` - Investigation of the Effects of Balance Training on Balance and Functional Status Patients With Total Hip Arthroplasty	N/A
Recruiting	`NCT06025448` - Is MIO-RSA Noninferior to BIO-RSA When it Comes to Mechanical Implant Stability?	N/A
Recruiting	`NCT05459259` - Physiotherapy for Arthrofibrosis Following Knee Replacement.
Not yet recruiting	`NCT05736666` - Treadmill Perturbation Training for Fall Prevention After Total Knee Replacement	N/A
Active, not recruiting	`NCT03692364` - Evaluation of Metal-on-conventional-polyethylene vs Ceramic-on-ceramic Articulating Surfaces in Total Hip Arthroplasty	N/A
Completed	`NCT05013879` - Kinesiotape for Edema After Bilateral Total Knee Arthroplasty	N/A
Completed	`NCT04120324` - Incidence of 30 Day Return to Hospital Following Same Day Discharge Total Hip Arthroplasty