Clinical Trials Logo
  1. Home
  2. Arthropathy
  3. NCT03258697

The Pharmacokinetics and Effectiveness of Local LevoBupivacaine Injection on Primary Total Joint Replacement Model.

Arthropathy Clinical Trial

Official title:
The Pharmacokinetics and Effectiveness of Different Methods of Local LevoBupivacaine Injection, a Prospective Randomized Case Control Clinical Study on Primary Total Joint Replacement Model.

Clinical Trial Summary

Total joint replacement is an ideal procedure to treat end stage joint disease. Good post-op pain relief could accelerate patient recovery and rehabilitation, and decrease admission days and medical cost. Local injection of LevoBupivacaine is an effective method in post-operative pain control. The effectiveness of local analgesia was noticed clinically. However, thorough studies about the pharmacokinetics of LevoBupivacaine, maintenance of effect, influence of post-operative rehabilitation are not well studied in different way of injection. The purpose of this study is to evaluate and analyze the pharmacokinetics and effect of local Levobupivacaine injection in different ways, the amount of post-operative fentanyl requirement after local injection, time to first fentanyl request, pain score, immediate post-operative function, side effect of analgesic agents, and medical cost, and to improve the quality of total joint replacement post-operative care.

Clinical Trial Description

Single large dose of LevoBupivacaine had been proved good analgesic effect in total joint replacement surgery. However, the safety was not well studied. For better understanding the effect and safety of local analgesic agent, we choose LevoBupivacaine with different injection way to find out. We divide patient to three groups, for comparing the effectiveness of LevoBupivacaine, and safety of LevoBupivacaine by checking intra-blood concentration. The pre-emptive analgesics and post-operative analgesics were the same as routine protocol in other total joint replacement. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03258697
Study type Interventional
Source Chang Gung Memorial Hospital
Contact
Status Completed
Phase N/A
Start date October 17, 2017
Completion date May 31, 2019
View Details
See also
  Status Clinical Trial Phase
Completed NCT02229331 - Biomechanical Determinants and Patterns Associated to the Pathophysiological Cascade of Ankle Arthropathy in Children With Haemophilia: Non-invasive In-vivo Measurement of Foot Joints in Children With Haemophilia During Gait.
Recruiting NCT05187936 - Pre-clinical Models for Mesenchymal Stem Cell Therapy in Hemophilic Arthropathy
Completed NCT04024176 - Gait Analysis in Moderate Hemophiliac Patients (AQM-Hemophile) N/A
Completed NCT04206033 - Hemophilia and Bone Metabolism: Study of Monocytic Populations and Inflammatory Proteins
Completed NCT06053060 - Evaluation of the Positioning of the Dynacup Cup "One C" Versus "Standard Dynacup" N/A
Recruiting NCT01300715 - An Alternative Technique for Lumbar Medial Branch Radiofrequency: Comparison With the Empirical Technique N/A
Terminated NCT05215600 - Anaverse™ Glenoid System and Its Instrumentation
Recruiting NCT04826380 - Thumb Basal Joint (CMC I) Arthritis - Preoperative Anxiety/Depression, Outcome Instruments, Carpal Cinematics and Cost-utility N/A
Recruiting NCT05591859 - Restoration Anatomic Acetabular Shell Revision Study N/A
Recruiting NCT05295004 - The Effect of Mindfulness Training Before Primary Total Joint Arthroplasty on Sleep Quality N/A
Completed NCT06002139 - Virtual Reality in Orthopedic Rehabilitation N/A
Recruiting NCT05459948 - The Medacta GMK SpheriKA Post-Marketing Surveillance Study
Enrolling by invitation NCT04618237 - Observational Study of Long-Term Joint Health Outcome in Hemophilia Patient
Recruiting NCT05292339 - Ketorolac in Upper Extremity Tendinopathy and Arthropathy Phase 4
Completed NCT03485170 - PET Imaging of Hemophilic Arthropathy N/A
Recruiting NCT05629130 - Embolization in Hereditary Coagulopathies N/A
Recruiting NCT05840705 - Approach Modification for Total Knee Arthroplasty in Morbidly Obese Patients N/A
Completed NCT06440863 - Postoperative BMI Changes and Functional Outcomes in Knee and Hip Arthroplasty N/A
Completed NCT05217264 - Adaptation of High Activity Arthroplasty Score to Turkish
Recruiting NCT05602753 - Smoking Cessation Study