Effect of Preoperative Steroid in Total Knee Arthroplasty

Status Not yet recruiting

Clinical Trial Summary

Detect the effect of preoperative steroid injection in total knee arthroplasty on post operative:

1. pain

2. oedema

3. nausea and vomiting

4. quadriceps power

5. knee flexion

6. wound complications

Clinical Trial Description

Total knee arthroplasty has been identified as one of the most effective surgeries for knee arthritis. Many patients experience moderate to severe pain during the early postoperative period, as the surgery involves extensive bone resection and postsurgical serum levels of cytokine interleukin-6 and C-reactive protein may be elevated.Furthermore, many patients suffer postoperative nausea and vomiting after total knee arthroplasty . The inflammatory response after TKA is pronounced and a result of cumulative effects of anaesthesia and mechanical stress . Inadequate management of postoperative pain is relevant with a series of undesirable effects, including progression to a persistent pain, delayed functional recovery, increased the economic burden and patient dissatisfaction. Steroids may be associated with decreased levels of interleukin-6 and C reactive protein and may, thus, relieve the pain associated with surgery. Dexamethasone is a long-acting glucocorticoid that has been reported to inhibit peripheral phospholipase A, which decreases the pain-aggravating agents from the cyclooxygenase and lipoxygenase pathways . In addition, it reduces postoperative nausea and vomiting by exerting a central antiemetic effect by inhibiting prostaglandin synthesis and the release of endogenous opioids[5] . Some studies also reported potential adverse events, such as infection . ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04084912
Study type	Interventional
Source	Assiut University
Contact	David Nady, physician
Phone	+2001203649367
Email	david011183@med.au.edu.eg
Status	Not yet recruiting
Phase	Phase 3
Start date	January 1, 2020
Completion date	June 1, 2021

View Details

See also
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