Clinical Trials Logo
  1. Home
  2. Arthropathy of Hip
  3. NCT03822793

A Dose-response Study of Tranexamic Acid in Total Hip Arthroplasty — PRADO  

Arthropathy of Hip Clinical Trial

Official title:
Dose Study of Tranexamic Acid in Total Hip Replacement to Reduce Post-operative Hemoglobin Loss: A Phase 2 Randomized Double-blind Monocentric Study

Clinical Trial Summary

A single preoperative dose of tranexamic acid (TXA) reduces blood loss and red blood cell transfusion in primary hip arthroplasty. Numerous regimens have been tested, ranging from 10mg/kg up to 3g. However the optimal dose to administer is unknown.

Clinical Trial Description

This dose-response study is a randomized double blind study with five groups of 30 patients each. Patients will be randomized to placebo, tranexamic acid (TXA) 300 mg, tranexamic acid (TXA) 500 mg, tranexamic acid (TXA) 1000 mg or tranexamic acid (TXA) 3000 mg. In addition a pharmacokinetic/pharmacodynamic study will be performed to identify the contribution of tranexamic acid (TXA) plasma concentration as a predictor of intra and postoperative D-Dimer values. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03822793
Study type Interventional
Source Centre Hospitalier Universitaire de Saint Etienne
Contact Julien LANOISELEE, MD
Phone (0)477828554
Email julien.lanoiselee@chu-st-etienne.fr
Status Recruiting
Phase Phase 2
Start date December 7, 2023
Completion date December 2026
View Details
See also
  Status Clinical Trial Phase
Terminated NCT03940651 - Cardiac and Renal Biomarkers in Arthroplasty Surgery Phase 4
Recruiting NCT05649007 - Post-marketing Surveillance Study of the Saphir Stem in Primary Hip Surgery
Completed NCT04690647 - The Efficacy of Suprainguinal Fascia Iliaca Compartment Block for Analgesia After Elective Total Hip Replacement. N/A
Active, not recruiting NCT04322916 - Clinical Study With the RM Pressfit Vitamys Cup in Combination With a Mathys Stem
Completed NCT05399043 - Experience of Use and Biopsychosocial Effects of Robotic and Virtual Reality Devices in Neuromotor Rehabilitation N/A
Terminated NCT03185117 - Opioid Consumption After Hospital Discharge in Orthopedic Surgery
Recruiting NCT02884349 - The Relationship Between Component Position and RoM N/A
Completed NCT02404727 - Evaluation of Cemented and Cementless Fixation of Dual-mobility Hip Prosthesis in Elderly Patients With Osteoarthritis N/A
Completed NCT03282201 - A Survey on Blood Transfusions in Major Artrhoplasty Operations
Recruiting NCT05647629 - Observational Study of the Development of Low Back Pain After Total Hip Arthroplasty.
Recruiting NCT01135160 - Evaluation of Weight Bearing After Total Hip and Knee Replacement
Recruiting NCT06147401 - Comparison of PENG Associated With LFCN Block Versus FICB for Multimodal Analgesic Management in THA N/A
Not yet recruiting NCT06024161 - Weight Change and the Risk of Chronic Pain Following Hip and Knee Arthroplasties
Completed NCT01103882 - Short-Term Clinical Outcome of Total Hip Arthroplasty Using Larger Diameter of 4th Generation Ceramic Bearing
Not yet recruiting NCT06415825 - Preliminary Muscle Contraction in the Rehabilitation and Prevention of Degenerative Pain in the Locomotor System N/A
Completed NCT03219294 - Does Deep Neuromuscular Blockade Improve Operating Conditions During Total Hip Replacements? Phase 4
Completed NCT03834142 - NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties, Bariatric, and Kidney Transplant Surgeries N/A
Completed NCT04333264 - Clinical Analysis of Suction Drainage in Cementless Hip Replacement N/A
Completed NCT00859976 - Study Comparing BoneMaster Hydroxyapatite Coating With Plasma-sprayed Hydroxyapatite Coating on Acetabular Cups N/A
Completed NCT03875976 - Total Hip Arthroplasty: Fast Track Protocol is the Future? N/A