Arthropathy of Knee Clinical Trial
Official title:
The Effect of Blood Transfusion on Recovery After Major Arthroplasties
The rate of hip, knee arthroplasties and their revision are increasing every year. The
incidence of blood transfusion in these operations are reported 18%, 68%, and 39%, 67%,
respectively. Blood transfusion is known to increase the risk of pulmonary, septic, wound and
thromboembolic complications and is related to mortality. Restrictive transfusion protocols
has cost-effective results in terms of reducing these complications, promoting early
discharge and reduced frequency of re-admission.
Within this context, we aimed to evaluate the transfusion practice in our hospital, define
the transfusion indicators and compare the transfused and non transfused patients in terms of
recovery.
After obtaining ethical approval Patients undergoing hip or knee arthroplasty or revision
arthroplasty will be included in this prospective observational study.
Patient characteristics (age , gender, body mass index, ASA physical status, anticoagulant
medication) Preoperative: hemoglobin, hematocrit, platelet, INR, APTT, PT values, the
precence of preoperative anemia, anemia treatment modalities will be recorded.
Intraopreative: type and duration of surgery, anesthesia method, monitoring methods used, the
amount of intraoprative adminestred fluids (crystalloid-colloid), amount of hemorrhage
Postoperative: hemoglobin-hematocrit-platelet leve The amount of blood transfusion and the
product used (erythrocyte suspension, fresh frozen plasma, thrombocyte-fibrinogen-factor
concentration-cryoprecipitate-other ) Hemoglobin-hematocrit-platelet level before and after
transfusion Indications for transfusion; hemoglobin threshold / physiological transfusion
indicator; tachycardia, hypotension, low flow rate, desaturation, low SvO2, inotropic
requirement, etc. / comorbidities / monitorisation findings, other, Discharge time of
patients Early upright position (postoperative 2nd day), information on walking capacities
(TUG - The Time Up and Go test) will be recorded and compared between transfused and
non-transfused patients
;
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