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Arthrogryposis clinical trials

View clinical trials related to Arthrogryposis.

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NCT ID: NCT06461286 Not yet recruiting - Clinical trials for Autosomal Dominant Optic Atrophy

SAD of IVT PYC-001 in OPA1 Mutation-Associated Autosomal Dominant Optic Atrophy (Sundew)

Start date: July 2024
Phase: Phase 1
Study type: Interventional

A First-in-Human multi-centre, prospective, Phase1a, Single Ascending Dose (SAD) interventional study of PYC-001 in participants with confirmed OPA1 mutation (haploinsufficiency) associated ADOA.

NCT ID: NCT06435858 Not yet recruiting - Clinical trials for Autosomal Dominant Polycystic Kidney Disease

Short-term Effects of an SGLT2 Inhibitor on Divalent Ions in Autosomal Dominant Polycystic Kidney Disease

SIDIA
Start date: September 1, 2024
Phase: Phase 4
Study type: Interventional

This study aims to better understand electrolyte handling in patients with autosomal dominant polycystic kidney disease treated with the SGLT2 inhibitor Empagliflozin. Patients will be randomized into two groups and take Empagliflozin or a Placebo for 2 weeks with a wash-out period of 2 weeks. The primary outcome is tubular handling of the divalent ions calcium, phosphate and magnesium. Secondary outcomes include diuresis, safety and tolerability.

NCT ID: NCT06372821 Not yet recruiting - Alzheimer Disease Clinical Trials

A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK

NIO-SILK
Start date: May 2024
Phase: Phase 1
Study type: Interventional

This study will assess if drug (NIO752) reduces production of a protein, tau, by the brain. Normally tau maintains the internal skeleton of nerve cells. In Alzheimer's disease (AD) it builds up in the brain, causing damage. Abnormal tau proteins cling to each other forming 'tangles' inside nerve cells, which interfere with how the nerve cells work, and eventually die. This is what causes the symptoms of dementia. It is thought that NIO752 reduces production of tau.

NCT ID: NCT06192134 Not yet recruiting - Arthrogryposis Clinical Trials

Continuous Passive Motion Device for Children With Arthrogryposis

Start date: June 2024
Phase: N/A
Study type: Interventional

The Investigators are investigating a continuous passive motion device to exercise the knee of young children with arthrogryposis after they have had knee surgery.

NCT ID: NCT06130592 Not yet recruiting - Clinical trials for Arthrogryposis Multiplex Congenita (AMC)

Technical Feasibility Study of Ultrasound Muscle Imaging in Antenatal Ultrasound

FetUS
Start date: January 1, 2024
Phase: N/A
Study type: Interventional

The objective of the study is to evaluate the performance of muscle ultrasound sections on antenatal ultrasound between 21-24 amenorrhea weeks for the screening of muscle atrophy, in a sample of low-risk and high-risk pregnancies of congenital multiple arthrogryposis