Arthritis Clinical Trial
Official title:
The "DeSScipher" Project - to Decipher the Best Treatment for Systemic Sclerosis - Observational Trial 2: Improvement of Hand Dysfunction by Arthritis in Systemic Sclerosis
Systemic sclerosis (SSc) is an orphan, multiorgan disease affecting the connective tissue of
the skin and several internal organs. Beside skin involvement, digital ulcers, tendinitis,
calcinosis and flexion contractures, the presence of hand arthritis is a major contributor
to impairment of hand function in systemic sclerosis. Several immunomodulatory drugs used in
other rheumatic diseases (including methotrexate, leflunomide, azathioprine, mycophenolate
mofetil and low-dose corticosteroids) can potentially improve arthritis and consequently
hand function in systemic sclerosis. For the assessment of arthritis, the CDAI (clinical
disease activity index) is validated in rheumatoid arthritis, and may be useful for
SSc-related arthritis, too.
This observational trial is part of the collaborative project "DeSScipher", one out of five
observational trials to decipher the optimal management of systemic sclerosis. Aim of this
observational trial is to:
- investigate the efficacy and safety of different treatments on hand dysfunction in
systemic sclerosis patients with hand arthritis and
- to validate the CDAI for arthritis in systemic sclerosis.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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