Synovial Fluid Bank From Arthritic Patients

Status Recruiting

Clinical Trial Summary

The objectives of this group project is to collect synovial fluid (SF) and paired sera and carry out preclinical studies to evaluate, alone or by combination testings, the potential of novel biomarkers for their prevalence and diagnostic/prognostic values in patients with arthritis, and to determine how therapeutic intervention regulate their levels.

Clinical Trial Description

Our group has developed interdisciplinary expertise in biomarkers related to distinct aspects of inflammation-induced joint damage, most notably those associated with degradation of components of the extracellular matrix, bone loss, or associated with post-translational changes on protease inhibitors. The objectives of this group project is to collect SF and paired sera and carry out preclinical studies to evaluate, alone or by combination testings, the potential of novel biomarkers for their prevalence and diagnostic/prognostic values in patients with arthritis, and to determine how therapeutic intervention regulate their levels. More specifically, we will study (1) biomarkers associated with osteoclastic bone resorption and synthesis/degradation of cartilage, (2) inhibitors of enzymes (calpastatin) that are preferentially targeted by rheumatoid patients, as well as (3) enzymes (e.g. Matrix Metalloproteinases (MMPs)) responsible for the cleavage of components of the articular cartilage. Finally, we propose to characterize the repertoire of specific active proteases in the SF of arthritic patients concomitantly to the use biomarkers (neoepitopes of cleaved collagens) previously associated with cartilage destruction and synthesis to identify new targets for the development of protease inhibitors for the treatment of arthritis. Furthermore, our project will also provide the opportunity to test the potential of measuring the net proteolytic activity by Fluorescent-Activated Substrate Conversion as a method of monitoring disease activity and treatment efficiency in a clinical setting. ;

Study Design

Related Conditions & MeSH terms

Arthritis

Clinical Trial Details

NCT number	NCT00512343
Study type	Observational
Source	Université de Sherbrooke
Contact	Gilles Boire, MD, MSc
Phone	(819) 564-5261
Email	Gilles.Boire@USherbrooke.ca
Status	Recruiting
Phase
Start date	June 2002
Completion date	September 2030

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04228458` - ThermRheum Version 1	N/A
Withdrawn	`NCT04976972` - A Comparison of Patients Receiving a Total Knee Replacement With Robotic Assistance or With Conventional Instrumentation	N/A
Completed	`NCT04037436` - Functional Exercise and Nutrition Education Program for Older Adults	N/A
Completed	`NCT00069342` - Health Beliefs and Health Behaviors Among Minorities With Rheumatic Diseases
Completed	`NCT02944448` - A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip or Knee	Phase 2
Recruiting	`NCT02498808` - Interferon-lambda: Novel Biologics for Controlling Neutrophil-mediated Pathology in Rheumatic Diseases?	N/A
Recruiting	`NCT02777060` - Exploring the Effectiveness of Sensor-based Balance Training on Patient Outcome Measures	N/A
Enrolling by invitation	`NCT02487888` - A Study of the Impact of Genetic Testing on Clinical Decision Making and Patient Care	N/A
Withdrawn	`NCT02136251` - Total Shoulder Replacement Outcomes With Autologous Bone Graft as Fixator for Glenoid Anchor Peg.
Completed	`NCT02143206` - Modifying Exercise for the COPD Patient
Completed	`NCT01407874` - A Randomized, Double-Blind, Dose-Response Study of the Safety and Uric Acid Effects of Oral Ulodesine Added to Allopurinol in Subjects With Gout and Concomitant Moderate Renal Insufficiency	Phase 2
Completed	`NCT01285843` - Periprosthetic Bone Mineral Density After Total Hip Arthroplasty Performed Through a Minimally Invasive Anterior Approach (AMIS) With Either an AMIStem or a Quadra Femoral Component	N/A
Completed	`NCT01172327` - Self-Directed Exercise Program for Adults With Arthritis	N/A
Completed	`NCT00987870` - Safety and Efficacy of BFH772 in Psoriasis Patients	Phase 1/Phase 2
Completed	`NCT01184924` - Evaluation of the Arthritis Foundation Tai Chi Program	N/A
Completed	`NCT00750984` - A Comparison of Two Different Surgical Techniques for Total Hip Resurfacing	N/A
Active, not recruiting	`NCT00611585` - A Safety and Efficacy Study of the Birmingham Hip Resurfacing System	N/A
Completed	`NCT00379184` - Sensitization in Osteoarthritic Knees	N/A
Completed	`NCT00403676` - Nursing Consultation in Out-patient Clinics for Patients With Inflammatory Rheumatic Disease	N/A
Completed	`NCT00175448` - Comparison of Physiotherapy Versus Home Exercise Following Hip Replacement Surgery	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.