Effect of Selective COX-2 Inhibition on Ulcer Healing

Status Completed

Clinical Trial Summary

The purpose of this study is to compare the effect of Famotidine plus a COX-2 inhibitor (celecoxib) with Famotidine plus dologesics in ulcer healing in arthritis patients.

Clinical Trial Description

For many years the integrity of the stomach mucosal barrier is thought to be maintained by mucosal prostaglandins (PG) synthesized by COX-1. However, the notion that COX-1 protects the stomach and COX-2 induces inflammation may be over-simplistic. In animal studies, COX-2, but not COX-1, is expressed in experimental gastric ulcer. Inhibition of COX-2 delays ulcer healing, indicating that PG derived from COX-2 contributes to restoring the mucosal barrier [1]. Whether this animal observation can be generalized to the human stomach is unknown. To date the biological functions of COX-1 and COX-2 in the healing of human gastric ulcer healing is unclear. Unlike experimental ulcers that only express COX-2, recently we have shown that both COX-1 and COX-2 are up-regulated in human gastric ulcers [2]. Furthermore, our preliminary results suggest that inhibition of COX-2 alone may not lead to a clinically significant delay in ulcer healing (refer to progress report). These observations suggest that peptic ulcer healing is more complex in the human stomach - both COX isoforms may be involved in the healing process. Inhibition of COX-2 alone may have less adverse effect than non-selective inhibition of both COX isoforms in ulcer healing. The current study aims to resolve the functional significance of COX-2 in human gastric ulcer from a biological and clinical perspective. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00153673
Study type	Interventional
Source	Chinese University of Hong Kong
Contact
Status	Completed
Phase	Phase 3
Start date	February 2001
Completion date	April 12, 2017

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04228458` - ThermRheum Version 1	N/A
Withdrawn	`NCT04976972` - A Comparison of Patients Receiving a Total Knee Replacement With Robotic Assistance or With Conventional Instrumentation	N/A
Completed	`NCT04037436` - Functional Exercise and Nutrition Education Program for Older Adults	N/A
Completed	`NCT00069342` - Health Beliefs and Health Behaviors Among Minorities With Rheumatic Diseases
Completed	`NCT02944448` - A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip or Knee	Phase 2
Recruiting	`NCT02498808` - Interferon-lambda: Novel Biologics for Controlling Neutrophil-mediated Pathology in Rheumatic Diseases?	N/A
Recruiting	`NCT02777060` - Exploring the Effectiveness of Sensor-based Balance Training on Patient Outcome Measures	N/A
Enrolling by invitation	`NCT02487888` - A Study of the Impact of Genetic Testing on Clinical Decision Making and Patient Care	N/A
Withdrawn	`NCT02136251` - Total Shoulder Replacement Outcomes With Autologous Bone Graft as Fixator for Glenoid Anchor Peg.
Completed	`NCT02143206` - Modifying Exercise for the COPD Patient
Completed	`NCT01407874` - A Randomized, Double-Blind, Dose-Response Study of the Safety and Uric Acid Effects of Oral Ulodesine Added to Allopurinol in Subjects With Gout and Concomitant Moderate Renal Insufficiency	Phase 2
Completed	`NCT01285843` - Periprosthetic Bone Mineral Density After Total Hip Arthroplasty Performed Through a Minimally Invasive Anterior Approach (AMIS) With Either an AMIStem or a Quadra Femoral Component	N/A
Completed	`NCT01172327` - Self-Directed Exercise Program for Adults With Arthritis	N/A
Completed	`NCT00987870` - Safety and Efficacy of BFH772 in Psoriasis Patients	Phase 1/Phase 2
Completed	`NCT00750984` - A Comparison of Two Different Surgical Techniques for Total Hip Resurfacing	N/A
Completed	`NCT01184924` - Evaluation of the Arthritis Foundation Tai Chi Program	N/A
Active, not recruiting	`NCT00611585` - A Safety and Efficacy Study of the Birmingham Hip Resurfacing System	N/A
Completed	`NCT00379184` - Sensitization in Osteoarthritic Knees	N/A
Completed	`NCT00403676` - Nursing Consultation in Out-patient Clinics for Patients With Inflammatory Rheumatic Disease	N/A
Completed	`NCT00175448` - Comparison of Physiotherapy Versus Home Exercise Following Hip Replacement Surgery	N/A