Corticosteroid Therapy for Persistent Synovitis in Acute Septic Arthritis on Native Joint

Arthritis, Septic Clinical Trial

— SYNOVITIS  

Official title:

Corticosteroid Therapy for Persistent Synovitis in Acute Septic Arthritis on Native Joint

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05531227
• Other study ID #: 8654
• Status: Recruiting
• Start date: June 20, 2022
• Est. completion date: December 13, 2023

Study information

• Verified date: June 2022
• Source: University Hospital, Strasbourg, France
• Contact: Jeannot GAUDIAS, MD
• Phone: 33 3 68 76 50 64
• Email: jeannot.gaudias[@]chru-strasbourg.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Acute septic arthritis is a rare but life-threatening and functionally serious disease. The improvement or disappearance of pain and functional recovery are sometimes difficult to obtain, with in some cases the persistence of synovitis due to a prolonged local inflammatory response, despite early and effective treatment. The consequences are significant for patients with often significant chronic pain, repercussions on autonomy and/or profession. An unfavorable evolution with joint destruction and need for replacement by a prosthesis is not uncommon.

Corticosteroid therapy is widely used in rheumatology in similar tables, for the purpose of drug synovectomy, with good results. The risk of infection remains the main contraindication to its use.

There are very few studies on its use in septic arthritis, either fundamentally or in humans, for which there are no data in adults. However, these have shown results encouraging the investigators not to neglect this therapy.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: December 13, 2023
• Est. primary completion date: December 13, 2023
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion criteria:

• Adult patient (=18 years old)

• having presented with septic arthritis and treated at the Strasbourg University Hospital between January 1, 2012 and December 31, 2021

• clinical finding of persistent synovitis, defined by the presence of pain, effusion or joint stiffness despite well-conducted treatment

• having had a diagnosis of joint infection proven by a positive culture of the joint fluid to a pathogenic germ

• having had treatment with local or systemic corticosteroids.

Exclusion criteria:

• Patient who has expressed his opposition to the reuse of his data for scientific research purposes.

• Absence of corticosteroid treatment

Related Conditions & MeSH terms

• Arthritis
• Arthritis, Infectious
• Arthritis, Septic
• Synovitis

Locations

Country	Name	City	State
France	Service de Chirurgie Orthopédique Septique - CHU de Strasbourg - France	Strasbourg

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Strasbourg, France

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Complete regression of the pain in a fast way		6 months after treatment with corticosteroids