Arthritis, Rheumatoid Clinical Trial
Official title:
Evolution of Adipokines and Body Composition in Rheumatoid Arthritis Patients Receiving Tocilizumab Therapy
The aim of this study is to analyze the variation of adiponectinemia and its molecular forms in RA patients receiving tocilizumab therapy.
Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with cardiovascular
morbidity. Tocilizumab (TCZ), a monoclonal antibody against the interleukin-6 receptor is an
effective new biotherapy for the treatment of RA. This treatment is associated with increased
LDL and HDL-cholesterol lipid parameters. Adipokines are adipose tissue-specific secreted
molecules, which have many functions such as regulation of appetite, blood glucose or immune
response. Among the adipokines, adiponectin exerts beneficial effects on the cardiovascular
system. Patients with RA also exhibit body composition changes, including an increase in
abdominal visceral fat. The impact of tocilizumab therapy in RA patients on adipokines and
body composition is not known.
This project aims to explore the evolution of circulating adiponectin and other adipokines
during tocilizumab therapy in RA. Body composition and its variations under tocilizumab
therapy will also be analyzed.
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