Arthritis, Rheumatoid Clinical Trial
Rheumatoid arthritis is a chronic inflammatory systemic disease. It has a worldwide
distribution and can affect all age group. The peak incidence is between fourth and sixth
decade. It is more prevalent in women, and it’s prevalence in the general population in
North America is between 0.2-1.5%. The etiology of RA is unknown, although clusters of the
disease in families and high concordance in mono-zydotic twins support genetic
predisposition. The prevalence of fatty liver disease in patients with rheumatoid arthritis
is currently unknown. We wish to study the link between the two conditions by performing a
son graphic imaging of the liver in a cohort of RA patients. If indeed a high prevalence of
NAFLD will be found in the RA patients, further support will be landed for the link between
inflammation and fatty liver disease. These findings may also have implications regarding
the management and follow up of RA patients.
The validity of sonographic imaging for detection of fatty liver diseases is currently
accepted: On ultrasonographic, fatty infiltration of the liver produces a diffuse increase
in echogenicity as compared with that of the kidneys. Ultrasonography has a sensitivity of
89% and a specificity of 93% in detecting steatosis and sensitivity and specificity of 77%
and 89% respectively in detecting increase fibrosis.
In view of all the above data, we expected to find higher prevalence of fatty liver in the
patients with higher inflammation markers compare with patients with lower markers.
n/a
Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
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|
Phase 3 | |
| Completed |
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|
Phase 1 | |
| Active, not recruiting |
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Anatomical Shoulder Domelock System Study
|
||
| Completed |
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A Two-Part, 12-Week Study of Etoricoxib as a Treatment for Rheumatoid Arthritis (RA) (MK-0663-107)
|
Phase 3 | |
| Completed |
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|
Phase 1 | |
| Completed |
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A Study to Evaluate the Long-term Safety and Efficacy of ASP015K in Subjects Previously Enrolled in a Phase 2 ASP015K Rheumatoid Arthritis Study
|
Phase 2 | |
| Completed |
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Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of SKI-O-703 in Healthy Volunteers
|
Phase 1 | |
| Withdrawn |
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Pharmacokinetics and Dosimetry of Tc 99m Tilmanocept Following a Single Intravenous Dose Administration in Male and Female Subjects Diagnosed With Rheumatoid Arthritis (RA)
|
Phase 1 | |
| Completed |
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Comparison of Compliance and Evolution of Functional Capacity of Patients With Rheumatoid Arthritis Treated by Methotrexate Either by Auto-injector or by Conventional Sub-cutaneous Syringe
|
Phase 3 | |
| Completed |
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MTX Discontinuation and Vaccine Response
|
Phase 4 | |
| Active, not recruiting |
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Treat-to-target in RA: Collaboration To Improve adOption and adhereNce
|
N/A | |
| Completed |
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|
||
| Completed |
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|
Phase 2 | |
| Withdrawn |
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|
Phase 2 | |
| Not yet recruiting |
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|
N/A | |
| Completed |
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Phase 3 | |
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Phase 3 | |
| Completed |
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Phase 4 | |
| Completed |
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Optimized Treatment Algorithm for Patients With Early Rheumatoid Arthritis (RA)
|
Phase 3 | |
| Completed |
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|
Phase 2 |