Arterial Line Clinical Trial
— PULCOOfficial title:
Pulmonary and Cardiac Ultrasound During Weaning From Mechanical Ventilation
Verified date | July 2014 |
Source | University Hospital, Clermont-Ferrand |
Contact | n/a |
Is FDA regulated | No |
Health authority | France: Ministry of Health |
Study type | Observational |
Prospective observational clinical multicentric study in ICU with ventilated patients requiring chest ultrasound analysis.
Status | Completed |
Enrollment | 100 |
Est. completion date | December 2010 |
Est. primary completion date | December 2010 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Adult patients ventilated more than 48 h - Stable respiratory and hemodynamic conditions for SBT - Consent of patients - Arterial line Exclusion Criteria: - Laryngeal dyspnea - Tracheostomy - Arythmya - No echogenicity - Paraplegia >T8 |
Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
France | CHU Clermont-Ferrand | Clermont-Ferrand |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Clermont-Ferrand | Groupe Hospitalier Pitie-Salpetriere |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Compare the change in pulmonary aeration during the test of weaning from mechanical ventilation (before, at the end, and 4-6 h after) between patients requiring re-ventilation before the 48th hour, and those weaned permanently. | Compare the change in pulmonary aeration during the test of weaning from mechanical ventilation (before, at the end, and 4-6 h after) between patients requiring re-ventilation before the 48th hour, and those weaned permanently. | before, at the end, and 4-6 h after | Yes |
Secondary | Studying variations, during weaning from mechanical ventilation, of pressure of left ventricle filling (E / Ea) coupled with those of plasma BNP. | Studying variations, during weaning from mechanical ventilation, of pressure of left ventricle filling (E / Ea) coupled with those of plasma BNP. | in the 4-6 early hours | Yes |
Secondary | Assessing the effects of E / Ea and BNP variations on the success or failure in the 4-6 early hours. | Assessing the effects of E / Ea and BNP variations on the success or failure in the 4-6 early hours. | in the 4-6 early hours. | Yes |
Secondary | Compare the variations of lung ultrasound score during the test of the weaning from mechanical ventilation between patients failed the spontaneous breathing test (SBT) and those extubated after successful SBT. | Compare the variations of lung ultrasound score during the test of the weaning from mechanical ventilation between patients failed the spontaneous breathing test (SBT) and those extubated after successful SBT. | in the 4-6 early hours | Yes |
Secondary | Comparison of levels epithelial and endothelial markers | at h0, h1, h4, h6 | Yes | |
Secondary | Constitution serum bank for epithelial (sRAGE) markers dosages | at h0, h1, h4, h6 | Yes | |
Secondary | constitution serum bank for endothelial (angiopoietin) markers dosages | at h0, h1, h4, h6 | Yes |
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