Anaesthesia Clinical Trial
Official title:
The Dynamic Effects of Phenylephrine on Preload and Cardiac Output in Patients Under General Anaesthesia
In patients under general anesthesia, episodes of hypotension are often treated with
phenylephrine. The effect of phenylephrine is conventionally attributed to afterload
increase.
The aim of the study is to describe the time course of the effects of phenylephrine on the
cardiac preload and cardiac output, and to evaluate whether phenylephrine, as an exclusive
alpha-mimetic, could be beneficial for preload optimisation.
In consecutive patients scheduled for laparoscopic sigmoidectomy, all hemodynamic and
respiratory variables are recorded electronically for subsequent offline analysis.
All patients are ventilated in volume control mode with a tidal volume of 8 ml/kg ideal body
weight.
During steady-state Target Controlled Infusion (TCI) propofol/remifentanil anesthesia, when
the Mean Arterial Blood Pressure (MAP) dropped below 80% of the awake state for at least 5
minutes, a phenylephrine bolus of 2 μg/kg is administered. If necessary this is repeated, or
a continuous administration of phenylephrine is started at a rate of 10-30 μg/kg/u.
All patient manipulations during the procedure are electronically recorded and time stamped
for subsequent off-line data analysis.
The first episode in each patient where phenylephrine is administered and in a period of at
least 10 minutes when minimal or absent patient manipulation occurred, the hemodynamic
variables are analysed to describe the effects of phenylephrine administration on the
dynamic preload parameters and macro-hemodynamics.
;
Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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