Arrhythmia Clinical Trial
Official title:
The Comparison of Antiarrhythmic and Myocardial Protective Effect Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft
Verified date | October 2014 |
Source | Samsung Medical Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | South Korea: Institutional Review Board |
Study type | Interventional |
The aim of the present study is to compare the antiarrhythmic and myocardial protective effect between lidocaine, dexmedetomidine, and their combined infusion in subjects undergoing coronary artery bypass graft.
Status | Completed |
Enrollment | 160 |
Est. completion date | February 2013 |
Est. primary completion date | February 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 20 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Those undergoing off-pump coronary artery bypass graft during the study period in Samsung Medical Center Exclusion Criteria: - Any patients with plasma aldosterone, or glucocorticoid disorder including primary hyperaldosteronism, renovascular hypertension, rennin-secreting tumor, salt-wasting renal disease, Cushing syndrome - Patients with recent exogenous steroid administration or previous diuretics therapy - Patients with recent myocardial infarction - Those undergoing unplanned cardiopulmonary bypass during the surgery |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor)
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Samsung Medical Center | Seoul |
Lead Sponsor | Collaborator |
---|---|
Samsung Medical Center |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Myocardial injury marker | Myocardial injury marker - CK-MB, and Troponin(i) blood level | postoperative ICU day 1 | No |
Primary | Myocardial injury marker | Myocardial injury marker - CK-MB, and Troponin(i) blood level | postoperative ICU day 2 | No |
Primary | Myocardial injury marker | Myocardial injury marker - CK-MB, and Troponin(i) blood level | postoperative ICU day 3 | No |
Secondary | The blood sodium, potassium, calcium level | The blood sodium, potassium, calcium level | 1 day before surgery day, at the start of anesthetic induction, 2 hour, 4 hour after anesthetic induction, postoperative ICU day 1, 2, 3 | No |
Secondary | The incidence of arrhythmia during and after the surgery | The incidence of arrhythmia during and after the surgery: Ventricular premature beat,Atrial premature complex, Bigeminy, Trigeminy, Atrial fibrillation, Ventricular tachycardia, Ventricular fibrillation, Atrio-Ventricular block, PSVT, Junctional rhythm, External pacing |
1 day before surgery day, at the start of anesthetic induction, 2 hour, 4 hour after anesthetic induction, postoperative ICU day 1, 2, 3 | Yes |
Secondary | Postoperative ICU stay, Hospital stay, Extubation time | Postoperative ICU stay, Hospital stay | 1 day after hospital discharge | No |
Secondary | Inotropics use during and after the surgery | Inotropics and other drug use during and after the surgery: Dopamine, NTG, dobutamine, milrinone, epinephrine, norepinephrine, amiodarone, diltiazem, remifentanil, esmolol, labetalol, nicardipine, Lasix, phenylephrine, lidocaine, sufentanil | 1 day before surgery day, at the start of anesthetic induction, 2 hour, 4 hour after anesthetic induction, , postoperative ICU day 1, 2, 3 | No |
Secondary | The incidence of hypokalemia | The incidence of hypokalemia | 1 day before surgery day, at the start of anesthetic induction, 2 hour, 4 hour after anesthetic induction, , postoperative ICU day 1, 2, 3 | No |
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