Sero-epidemiology of Priority Arboviruses in French Guiana

Arbovirus Infections Clinical Trial

— EPI-ARBO  

Official title:

Sero-epidemiology of Priority Arboviruses in French Guiana

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03210363
• Other study ID #: 2016-073
• Status: Completed
• Phase: N/A
• Start date: June 9, 2017
• Est. completion date: June 30, 2020

Study information

• Verified date: September 2020
• Source: Institut Pasteur
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Dengue is an important public health problem despite the efforts of local health authorities to mitigate the impact of epidemics and the epidemiology of dengue evolved from an endemo-epidemic to a hyper-endemic state. In late 2013, the first local transmission of chikungunya virus in the Americas was identified in Caribbean countries and territories including French Guiana. Rapidly, more than 16,000 suspected local Health authorities had reported cases. In May 2015, the Pan American Health Organization (PAHO) issued an alert regarding the first confirmed Zika virus infections in Brazil. The emergence of Zika virus in South America led to a rapid spread throughout South and Central America, reaching French Guiana in December 2015. With the increasing frequency of epidemics related to arbovirus and the resulting health, social, and economic impacts of dengue, the surveillance of arbovirus have become social, political, and public health challenges that require specific and non-available immune status information.

Description:

French Guiana is a 250,000 inhabitant's French overseas department located in South America, the epidemiology of arboviruses has recently evolved and marked by important outbreaks.

Dengue remains an important public health problem despite the efforts of local health authorities to mitigate the impact of epidemics and the epidemiology of dengue evolved from an endemo-epidemic to a hyper-endemic state. In late 2013, the first local transmission of chikungunya virus in the Americas was identified in Caribbean countries and territories including French Guiana. Rapidly, more than 16,000 suspected local Health authorities had reported cases. In May 2015, the Pan American Health Organization (PAHO) issued an alert regarding the first confirmed Zika virus infections in Brazil. The emergence of Zika virus in South America led to a rapid spread throughout South and Central America, reaching French Guiana in December 2015. With the increasing frequency of epidemics related to arbovirus and the resulting health, social, and economic impacts of dengue, the surveillance of arbovirus have become social, political, and public health challenges that require specific and non-available immune status information.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 2697
• Est. completion date: June 30, 2020
• Est. primary completion date: November 21, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 2 Years to 75 Years

Eligibility

Inclusion Criteria:

• Guiana resident for at least 6 months and present during the entire study period

• Age between 2 and 75 years old

Exclusion Criteria:

• Subject under guardianship or deprived of liberty by judicial decision

• Subject with any pathology or health problem not compatible with blood sampling

Related Conditions & MeSH terms

• Arbovirus Infections

Intervention

Other:
• Human Biological samples
Blood sample

Locations

Country	Name	City	State
France	Institut Pasteur de la Guyane	Cayenne

Sponsors (1)

Lead Sponsor	Collaborator
Institut Pasteur

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Dengue infections proportion	Proportion of dengue primary and multiple infections in Guiana population.	2 years
Primary	Dengue, chikungunya, zika Antibodies detection by multiplex serologic tests	Description of the virological status of individuals by Mutiplex detection of antibodies directed against dengue, chikungunya and zika arboviruses.	2 years
Secondary	Seroprevalence by area and age	Estimatation of the frequency of Dengue, Chikungunya and zika infections among the general population of French Guiana by geographical area and by age class	2 years