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Scot Sweet Study (Interaction of a Non-nutritive Sweetener With a High-fibre Weight Loss Diet) — SSS  

Appetitive Behavior Clinical Trial

Official title:
Healthy Diets for a Healthy Weight: Exploring Physiological Mechanisms Related to Dietary Fibre and Non-Nutritive Sweeteners

Clinical Trial Summary

The investigators present a weight loss diet intervention study, to be conducted as a within-subject design, with all food and beverages provided, to assess interaction of non-nutritive sweetener (sucralose) with a high-fibre weight loss diet, on markers of gut health in humans. This study will allow assessment of the effects of a non-nutritive sweetener (sucralose) with a high-fibre (soluble fibre, fructo-oligosaccharides, FOS) diet on metabolic health and activity and composition of gut microbiota, by a controlled human diet intervention study. The investigators propose to recruit participants living with obesity, with a poor diet quality (moderate habitual fibre intake) to additionally address diet inequalities in the research approach, and this will also allow examine the time-course of adaptation of the gut microbiome (measured in faecal samples). The investigators will also assess changes in free-living glycaemic control with addition of dietary fibre and bio-markers of health.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05892003
Study type Interventional
Source University of Aberdeen
Contact Alexandra Johnstone, Prof
Phone 01224 438614
Email alex.johnstone@abdn.ac.uk
Status Recruiting
Phase N/A
Start date May 12, 2023
Completion date December 2024
View Details
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