The Effect of Soluble Fiber Dextrin on Subjective and Physiological Markers of Appetite

Appetitive Behavior Clinical Trial

Official title:

The Effect of Soluble Fiber Dextrin on Subjective and Physiological Markers of Appetite: a Randomized Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04596969
• Other study ID #: SFDISU
• Status: Completed
• Phase: N/A
• Start date: January 1, 2014
• Est. completion date: January 1, 2018

Study information

• Verified date: September 2020
• Source: Iowa State University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study examines the effect of soluble fiber dextrin on food intake, appetite, and physiological markers of appetite. Adults aged 18-45 years with a BMI were recruited for this study. Participants were given two doses of SFD in the morning and appetite, food intake and physiological markers of appetite were measured over 10 years.

Description:

Overweight and obesity are leading health problems. The study investigates the effect of a food ingredient from two different sources at two different doses on food intake and appetite markers over a 10 hour period. All participants reported to the laboratory first thing in the morning and remained in the laboratory until after their evening meal. A fixed breakfast was served but the participants were free to eat as much as they liked at lunch and dinner. Blood was taken at regular intervals during the day and assayed for glucose and several hormones related to appetite. Subjective measures of appetite were also collected over the 10 hour test session.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: January 1, 2018
• Est. primary completion date: January 1, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

BMI 19.9 - 29.9 Aged 18-45 Find the study foods to be palatable

Exclusion Criteria:

Weight change > 3kg in the past three months Do not regularly consume snacks Presence or history of GI disorders Restrained eater Used medication that influences appetite

Related Conditions & MeSH terms

• Appetitive Behavior

Intervention

Other:
• Soluble Fiber Dextrin
Ingredient based on resistant starch

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Iowa State University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Food intake	Food intake measured at lunch and evening meal.	10 hours
Secondary	Appetite	Subjective appetite measures using questionnaires at regular intervals over 10 hours,	10 hours
Secondary	CCK	Plasma CCK measured at regular intervals over 10 hours.	10 hours
Secondary	GLP-1	Plasma GLP-1 measured at regular intervals over 10 hours.	10 hours
Secondary	PYY3-36	Plasma PYY3-36 measured at regular intervals over 10 hours.	10 hours
Secondary	Breath Hydrogen	Breath hydrogen measured at regular intervals over 10 hours.	10 hours