Appendicitis Clinical Trial
Official title:
Conservative Versus Operative ManageMent of Acute Uncomplicated Appendicitis
This study aims to compare antibiotic treatment versus surgery for patients with uncomplicated appendicitis.
The study will include patients aged 16 and over, with a first admission with right iliac fossa pain and a raised white cell count or C-reactive protein. Patients will be randomised electronically in a 1:1 ratio either to undergo emergency appendectomy or to receive intravenous antibiotics as an inpatient, until clinical and biochemical improvement is observed, followed by outpatient oral antibiotics. Those who have surgery will have 3 post-operative doses of intravenous antibiotics, unless perforation was identified at the time of surgery, in which case, microbiology will be contacted to advise regarding antibiotic choice and duration. Follow-up by telephone interview will be at 1 week, 1, 3 and 12-month intervals. ;
Status | Clinical Trial | Phase | |
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Completed |
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N/A | |
Withdrawn |
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Phase 1/Phase 2 | |
Recruiting |
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Recruiting |
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N/A | |
Terminated |
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Completed |
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Terminated |
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Completed |
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Phase 3 | |
Completed |
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Phase 3 | |
Completed |
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||
Completed |
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Phase 4 | |
Completed |
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Completed |
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Completed |
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N/A | |
Completed |
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Active, not recruiting |
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Terminated |
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Phase 2 | |
Completed |
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