The Effect of Breastfeeding on the Development of Appendicitis in Adults

Appendicitis Clinical Trial

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT02679547
• Other study ID #: Breastfeeding
• Status: Enrolling by invitation
• Start date: January 2016
• Est. completion date: January 2020

Study information

• Verified date: February 2019
• Source: Sisli Hamidiye Etfal Training and Research Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Appendectomy is the most common emergent operative procedure performed worldwide. In this study investigators will investigate if there is a relationship between breast feeding and appendicitis in adults.

Description:

Acute appendicitis accounts for the commonest indication for emergency visits during daily surgical practice. Breast feeding is very important both mother and the child. For the infant, breast feeding has an important role on the maturity of immune system. In the literature search, there are a little studies about the relationship between the breast feeding and appendicitis. In the literature, some studies suggests that the breast feeding may possibly give protection against the development of appendicitis. But the number of the patients and the control groups are limited. Because of that the investigators have planned to make this study with a lot of number of patients.

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 1500
• Est. completion date: January 2020
• Est. primary completion date: December 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 40 Years

Eligibility

Inclusion Criteria:

• Subjects has pathologically proven appendicitis for appendicitis group.

Exclusion Criteria:

• Subjects has American Society of Anesthesiologists Physical Status classification 4,

• Subject has pregnancy,

• Subject has malignity,

• Subject has chronic illness,

• Subjects who won't accept to join the study

• Subjects who don't have family members

Related Conditions & MeSH terms

• Appendicitis

Intervention

Other:
• Breastfeeding
All of the participants and patients will have a questionnaire about their breastfeeding

Locations

Country	Name	City	State
Turkey	Bursa Yuksek Ihtisas Training and Research Hospital	Bursa
Turkey	Arnavutkoy State Hospital	Istanbul
Turkey	Bezmialem Vakif University	Istanbul
Turkey	Istanbul Training and Research Hospital	Istanbul
Turkey	Sisli Etfal Training and Research Hospital	Istanbul

Sponsors (5)

Lead Sponsor	Collaborator
Sisli Hamidiye Etfal Training and Research Hospital	Arnavutkoy State Hospital, Bezmialem Vakif University, Bursa Yüksek Ihtisas Education and Research Hospital, Istanbul Training and Research Hospital

Country where clinical trial is conducted

Turkey, 

References & Publications (3)

Alves JG, Figueiroa JN, Barros I. Does breast feeding provide protection against acute appendicitis? A case-control study. Trop Doct. 2008 Oct;38(4):235-6. doi: 10.1258/td.2008.070404. — View Citation

Minniti F, Comberiati P, Munblit D, Piacentini GL, Antoniazzi E, Zanoni L, Boner AL, Peroni DG. Breast-milk characteristics protecting against allergy. Endocr Metab Immune Disord Drug Targets. 2014 Mar;14(1):9-15. Review. — View Citation

Pisacane A, de Luca U, Impagliazzo N, Russo M, De Caprio C, Caracciolo G. Breast feeding and acute appendicitis. BMJ. 1995 Apr 1;310(6983):836-7. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The breastfeeding status questionnaire in the appendicitis patients and participants without appendicitis	500 patients who have pathologically proven appendicitis and 1000 controls without appendicitis will be asked the question which is "How long did you had breast feeding?". The patients and the participants will be in the same age groups. Also the same question will be asked to at least one of the family member (mother, father, older brother or older sister). The breastfeeding status will be in three group ( 0-2 months, 2-6 months and >6 months)	2 days