Appendicitis Clinical Trial
Official title:
An Antimicrobial Stewardship Intervention Program in Pediatric Surgery
Acute appendicitis is a common surgical emergency in children. Non-perforated appendicitis
patients do not require antibiotics after appendectomy. Although guidelines and
recommendations exist to decrease post-operative antibiotic mis-use after appendectomy,
surgeons continue to prescribe unwarranted antibiotics.
The aim of this study is to determine if an Antimicrobial Stewardship Program in Pediatric
Surgery will decrease the use of un-warranted antibiotics.
Many surgeons continue to treat non-perforated or "borderline perforated" appendicitis with
postoperative antibiotics despite an evidence-based definition of perforation (in the
pediatric surgical literature) and many guidelines and recommendations that specify that no
postoperative antibiotics are required. Children with perforated appendicitis are also often
treated with longer-than-necessary courses of antibiotics. Although surgeons may feel that
they only prescribe additional doses on occasion, evidence suggests that this behavior occurs
in over 50% of children with non-perforated appendicitis.
These additional doses contribute to a longer length of stay, excess costs to the health care
system, and disrupt patient flow. Additionally, the patients are exposed to more antibiotics
and their potential for adverse effects (such as incorrect dose, incorrect medication,
allergic reaction, antimicrobial resistance or c difficile infection).
Antimicrobial stewardship programs have been successful in pediatrics and adult general
surgery in curbing unwarranted antibiotic use, but have never been evaluated in pediatric
general surgery.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04529980 -
Probiotics and Antibiotic Associated Diarrhea in Pediatric Complicated Appendicitis
|
N/A | |
| Withdrawn |
NCT03528343 -
Narcotic vs. Non-narcotic Pain Regimens After Pediatric Appendectomy
|
Phase 1/Phase 2 | |
| Recruiting |
NCT03522233 -
Pediatric Appendicitis Risk Calculator (pARC) in Children With Appendix Ultrasounds
|
||
| Recruiting |
NCT03380793 -
A Trial to Assess the Efficacy and Safety of Morinidazole in Patients With Appendicitis
|
Phase 4 | |
| Recruiting |
NCT02108340 -
Comparative Study of Microwave Radiometry and Ultrasonography for the Diagnosis of Acute Appendicitis
|
N/A | |
| Terminated |
NCT02029781 -
The Laparoscopic Appendicitis Score; a Multicenter Validation Study
|
N/A | |
| Completed |
NCT01356641 -
Antibiotic Treatment Alone for Acute Simple Appendicitis in Children
|
N/A | |
| Terminated |
NCT00971438 -
Structured Management of Patients With Suspicion of Appendicitis Using a Clinical Score and Selective Imaging
|
N/A | |
| Completed |
NCT00913380 -
Diagnosis of Acute Appendicitis: Low-dose Computed Tomography (CT) Versus Standard-dose CT
|
Phase 3 | |
| Completed |
NCT01515293 -
Single Incision Versus Conventional Laparoscopic Appendectomy
|
Phase 3 | |
| Completed |
NCT00616616 -
Single Incision Laparoscopy
|
N/A | |
| Completed |
NCT00530998 -
Minimally Invasive Surgery: Using Natural Orfices
|
||
| Completed |
NCT00195351 -
Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection
|
Phase 4 | |
| Completed |
NCT02916134 -
Conservative Versus Operative ManageMent of Acute Uncomplicated Appendicitis
|
N/A | |
| Completed |
NCT04614649 -
Right Iliac Fossa Treatment-Turkey Audit
|
||
| Completed |
NCT04365491 -
European Society for Trauma and Emergency Surgery (ESTES) Cohort Study Snapshot Audit 2020 - Acute Appendicitis
|
||
| Completed |
NCT03770897 -
Laparoscopic Appendectomy Performed by Junior SUrgeonS: Impact of 3D Visualization on Surgical Outcome
|
N/A | |
| Completed |
NCT02507674 -
Point of Care 3D Ultrasound for Pediatric Appendicitis: a Pilot Study
|
||
| Active, not recruiting |
NCT01718275 -
Non-operative Management of Early Appendicitis in Children
|
||
| Terminated |
NCT01575028 -
Transversus Abdominis Plane (TAP) Versus Local Anesthetic for Lap Appendectomies
|
Phase 2 |