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NCT04431505 Clinical Trial

Anaesthesia and Apoptosis

Apoptosis Clinical Trial

Official title:
Effect of Anaesthesia on Apoptosis During Congenital Heart

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04431505
Other study ID # 13700420
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date June 12, 2020
Est. completion date December 11, 2020

Study information
Verified date July 2020
Source Assiut University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Anesthetics cause widespread apoptosis in the developing brain, resulting in neurocognitive abnormalities. However, it is unknown whether anesthesia-induced neurotoxicity occurs in humans because there is currently no modality to assess for neuronal apoptosis in vivo

Recruitment information / eligibility
Status Recruiting
Enrollment 20
Est. completion date December 11, 2020
Est. primary completion date December 1, 2020
Accepts healthy volunteers
Gender All
Age group 1 Year to 10 Years
Eligibility Inclusion Criteria:

- congenital heart corrective surgery

Exclusion Criteria:

- none

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• apoptosis
study of apoptotic changes due to anaesthesia

Locations
Country Name City State
Egypt Assiut university Assiut

Sponsors (1)
Lead Sponsor Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary apoptotis during anaesthesia measuring markers of apoptosis pathway 24 hours
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Completed NCT04607434 - Mechanism of Delayed Neutrophil Apoptosis in Acute Lung Injury
Recruiting NCT01267786 - The Effect of Volatile Anesthetics Sevoflurane and Desflurane on Liver, Renal and Cardiovascular Systems During Liver Surgery Phase 4