Acute and Chronic Effects of Dynamic Apnea in Healthy Untrained Subjects

Apnea Clinical Trial

— APNEX  

Official title:

Acute and Chronic Effects of Dynamic Apnea in Healthy Untrained Subjects

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03095677
• Other study ID #: CHRO-2015-01
• Status: Completed
• Phase: N/A
• Start date: April 8, 2016
• Est. completion date: November 20, 2017

Study information

• Verified date: May 2018
• Source: Centre Hospitalier Régional d'Orléans
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The inclusion of short periods of apnea (several seconds) during exercise (i.e. dynamic apnea) induces a significant decrease in blood oxygenation and muscle tissue. To date, the immediate effects ("acute apnea") of this decrease in the quantity of oxygen available at the muscle and brain level are poorly understood. Moreover, a physical training during which these short periods of apnea ("chronic apnea") would be included could lead to physiological adaptations and to improvement in physical performance similar to those obtained during altitude training.

The purpose of this study is to evaluate the effects of acute dynamic apnea on metabolism.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: November 20, 2017
• Est. primary completion date: November 20, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• The cutaneous thickness at the vastus lateralis level lower than 1.5 cm to obtain the reliable muscle oxygenation measurement

• Subjects will have to sign the inform consent before the beginning of the study

Exclusion Criteria:

• Contraindications to regular physical exercise practice

• To practice an endurance sport more than 1h/week

• Regular practice of apnea

• Chronic use of cannabis and/or alcohol

• Cardiac or metabolic pathology

• Asthma and/or bronchodilatator treatment

• ECG abnormality at rest

• Regular consumption of tobacco

Related Conditions & MeSH terms

• Apnea

Intervention

Other:
• Program of training with exercises including apnea
16 training session on cycle ergometry with exercises including apneas.
• Program of training with exercises without apnea
16 training session on cycle ergometry with exercises without apnea

Locations

Country	Name	City	State
France	CHR d'Orléans	Orléans

Sponsors (2)

Lead Sponsor	Collaborator
Centre Hospitalier Régional d'Orléans	Laboratoire de Complexité, Innovation et Activités Motrices et Sportives

Country where clinical trial is conducted

France, 

References & Publications (4)

Andersson JP, Linér MH, Rünow E, Schagatay EK. Diving response and arterial oxygen saturation during apnea and exercise in breath-hold divers. J Appl Physiol (1985). 2002 Sep;93(3):882-6. — View Citation

Caquelard F, Burnet H, Tagliarini F, Cauchy E, Richalet JP, Jammes Y. Effects of prolonged hypobaric hypoxia on human skeletal muscle function and electromyographic events. Clin Sci (Lond). 2000 Mar;98(3):329-37. — View Citation

de Bruijn R, Richardson M, Schagatay E. Increased erythropoietin concentration after repeated apneas in humans. Eur J Appl Physiol. 2008 Mar;102(5):609-13. Epub 2007 Dec 19. — View Citation

Dufour SP, Ponsot E, Zoll J, Doutreleau S, Lonsdorfer-Wolf E, Geny B, Lampert E, Flück M, Hoppeler H, Billat V, Mettauer B, Richard R, Lonsdorfer J. Exercise training in normobaric hypoxia in endurance runners. I. Improvement in aerobic performance capacity. J Appl Physiol (1985). 2006 Apr;100(4):1238-48. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Spectometry to measure hemoglobin rate	Measurement of oxygenation	3 weeks
Primary	Wingate test to measure maximum consumption of dioxygen	Measurement of aerobic performance	3 weeks
Primary	Measurement of hormonal markers	Measurement of Dehydroepiandrostenedione (DHEA)	3 weeks
Primary	Jaeger debimeter system to measure of peak oxygen	Measurement of oxygen consumptiom	3 weeks
Primary	Measurement of arterial saturation in dioxygen	Measurement by ear blood micro-sample	3 weeks
Primary	Spectometry to measure hemoglobin	Measurement of oxygenation	12 weeks
Primary	Measurement of hormonal markers	Measurement of Dehydroepiandrostenedione (DHEA)	12 weeks
Primary	Jaeger debimeter system to measure of peak oxygen	Measurement of oxygen consumption,	12 weeks
Primary	Measurement of arterial saturation in dioxygen	Measurement by ear blood micro-sample	12 weeks
Secondary	Cardiac frequency	measurement with a 12 lead - Electrocardiogamm	3 weeks
Secondary	Cardiac frequency	measurement with a 12 lead - Electrocardiogramm	12 weeks
Secondary	Borg scale to measure penibility of the effort		week 3
Secondary	Borg scale to measure penibility of the effort		week 12