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Quantitative MRI of Bone Marrow Fat Fraction in Patients With Trepanobiopsy

Aplastic Anemia Clinical Trial

Official title:
Clinical Study of the Sensitivity and Specificity of the Quantitative Assessment of Bone Marrow Cellularity by MRI in Comparison With Trepanobiopsies in Patients With Diseases of the Hematopoietic System

Clinical Trial Summary

The study is aimed to find correlation between the assessment of cellularity according to trepanobiopsy data and the results of measuring MRI parameters.

Clinical Trial Description

The ratio of fat to water in the bone marrow depends on the cellularity of the bone marrow. In addition to the water/fat ratio in bone marrow there are also other parameters for quantitative MRI assessment. These include the apparent diffusion coefficient (ACD), the T1 relaxation time, mapping of the macromolecular proton fraction. The undoubted advantage of MRI is its non-invasiveness and the ability to assess any localization of the bone marrow. MRI may become a new non-invasive method for assessing the cellularity of the bone marrow in children with oncohematological diseases. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04761965
Study type Interventional
Source Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Contact Nataliia Kriventsova
Phone +7 (495)2876570
Email nataliya.krivencova@fccho-moscow.ru
Status Recruiting
Phase N/A
Start date February 16, 2021
Completion date January 1, 2024
View Details
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