Aplastic Anemia Clinical Trial
Official title:
Phase III Randomized Study of Cyclophosphamide With or Without Antithymocyte Globulin Before Bone Marrow Transplantation in Patients With Aplastic Anemia
OBJECTIVES:
I. Compare outcome, including graft failure, graft versus host disease, and survival of
HLA-identical sibling bone marrow transplants for aplastic anemia using cyclophosphamide with
or without antithymocyte globulin as a conditioning regimen.
PROTOCOL OUTLINE: This is a randomized, multicenter study. Patients are randomized to receive
cyclophosphamide IV over 60 minutes on days -5 to -2 with or without antithymocyte globulin
IV over 4 hours.
All patients then receive bone marrow over 60-120 minutes on day 0, 36 hours after the last
dose of cyclophosphamide.
Patients are followed at day 100, at 6 months, and at 1 year posttransplant.
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