Apico Marginal Defects Clinical Trial
Official title:
Comparative Evaluation of Two PRF Formulations on Quality of Life and 2D and 3D Assessment of Healing Outcome of Apicomarginal Defects.
Healing of apicomarginal defects using 2 different formulations of PRF i.e PRF -high and PRF-medium will be assessed and compared using 2D and 3D criteria. Also, in vitro evaluation of the PRF formulations and quality of life will be compared between the two groups.
Periapical surgery is a viable treatment option in teeth with persistent apical
periodontitis, especially in cases which fail to heal by non surgical treatment. Kim and
Kratchman classified periradicular lesions into categories A-F. Lesions A-C are of endodontic
origin without any periodontal pockets and vary with respect to the size of periapical
radiolucency while D-F are combined endodontic - periodontal origin and are ranked accoding
to the magnitude of periodontal breakdown. Type F defects are commonly referred to as
apicomarginal defects and have worst prognosis among all. The lower success rate is
attributed to the apical migration of junctional epithelium and intrusion of non osteogenic
connective tissue into the periapical region.
Recently, autologous platelet concentrates have been used instead of the conventional
practice of using GTR barrier membranes for treating apicomarginal defects. Till date no
human study has compared platelet formulations; PRF-high ( 2700 rpm for 12minutes) and
PRF-medium (1500 rpm for 14minutes) to see any difference in the bony healing and the quality
of life between the two groups and no study have assessed bony healing of the periapical
defect with periodontal communication with the use of CBCT.
Thus, the aim of the present study is to investigate the effect of 2 different formulations
of PRF on quality of life and healing outcome of periapical defects with periodontal
communications . Also, in vitro histological and immunohistochemical evaluation and
comparison of the clots prepared from different centrifugation protocols will be done .
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT03905590 -
Efficacy of Guided Tissue Regeneration in the Healing of Periapical Defects With Periodontal Communication Using CBCT
|
N/A |