Clinical Trials Logo

Clinical Trial Summary

The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine needle anesthesia.


Clinical Trial Description

In June 2016, an intranasal delivery system of local anesthesia called Kovanaze, gained FDA approval. [9] Kovanaze is available as a 0.2 ml metered spray and is intended to achieve pulpal anesthesia of 5 maxillary teeth on either side of the face.

With the ability to avoid the traditional painful injection Kovanaze offers promise in the field of maxillary anesthesia and this study intends to:

1. Compare Kovanaze to conventional needle anesthetic for procedures other than fillings and/or involving multiple teeth in adults

2. Evaluate patient anxiety, tolerance and acceptability of Kovanaze in patients undergoing dental procedures ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04105985
Study type Interventional
Source Virginia Commonwealth University
Contact
Status Withdrawn
Phase Phase 2
Start date August 2020
Completion date August 2021

See also
  Status Clinical Trial Phase
Completed NCT04552132 - Postoperative Pain and Healing in Teeth Treated With GentleWave or EndoActivator N/A
Completed NCT04514991 - Bone Regenerative Techniques in Endodontic Microsurgery N/A
Withdrawn NCT04104789 - Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - General Phase 2
Completed NCT01904552 - Accuracy of ERCLMDs in Teeth With Apical Periodontitis Phase 1
Completed NCT05792787 - Association Between Apical Periodontitis and Atherosclerotic Cardiovascular Diseases
Completed NCT06072742 - Effect of Lifestyle on Caries and Apical Periodontitis
Completed NCT06226740 - Effectiveness of Different Obturation Techniques N/A
Completed NCT04126928 - Validation of PUFA Index in Assessing Untreated Dental Caries Among Malaysian Adult Subpopulation N/A
Recruiting NCT05439330 - Application of a Dental-dedicated MRI in the Diagnosis of Temporomandibular Joint Disorders, Tissue Alterations Related to Third Molars, Periapical and Periodontal Inflammatory Diseases, and Implant Treatment Planning N/A
Recruiting NCT06005545 - A Study to Compare Various Root Canal Cleaning Devices Based on Cavitation,Ultrasonic and Conventional Methods. N/A
Completed NCT02681276 - Clinical and Microbiological Evaluation of 0.5% Versus 3% Sodium Hypochlorite in Root Canal Treatment N/A
Completed NCT04072926 - Effects of PDT and Bioceramic Filling on Periapical Healing and Postoperative Pain After Endodontic Retreatment Early Phase 1
Completed NCT03711942 - Comparison of Healing of Apical Periodontitis in Periodontally Diseased and Healthy Patients. N/A
Completed NCT03409887 - Effect of Intraorifice Barrier on Healing of Apical Periodontitis N/A
Completed NCT03171376 - Effect of Coronal Extent of Obturation on Endo-perio Lesions N/A
Recruiting NCT06043453 - Revitalization of Traumatized Immature Permanent Teeth
Completed NCT03987659 - Therapeutic Irrigation Procedures to Treat Apical Periodontitis N/A
Completed NCT03288467 - Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment N/A
Recruiting NCT03527602 - FE in Anterior Teeth N/A
Completed NCT04545307 - Transplantation of Allogeneic MSC in Patients With Pulp Necrosis and Chronic Apical Periodontitis Phase 2/Phase 3