Clinical Trials Logo
  1. Home
  2. Aphthous Stomatitis
  3. NCT01293968

Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis

Aphthous Stomatitis Clinical Trial

Official title:
Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis

Clinical Trial Summary

The intention of the study is to study the effects of Ibuprofen, Diphenhydramine and Aluminium MgS in decreasing the signs of recurrent aphthous stomatitis (RAS)

Clinical Trial Description

Recurrent aphthous stomatitis (RAS) is the most painful oral lesion with a considerable prevalence . The most common aphthous ulcer treatments include applying topical agents such as antibiotics, Non Steroidal Anti Inflammatory Drugs (NSAIDs) to immunosuppressants.

The mixture of Diphenhydramine and Aluminum MgS suspension has been prescribed as an analgesic mouthwash for a long time in order to decrease a great number of oral ulcers symptoms such as aphthous ulcers. Ibuprofen is a potent NSAID with fair anti-inflammatory potential prescribed in dental pains.

This double-blind randomized clinical trial was conducted to assess the effect of Ibuprofen, Diphenhydramine and Aluminium MgS mixture on symptoms of aphthous ulcers.40 patients will be participating in this study,20 will receive the mixture of Diphenhydramine and Aluminium MgS while the other group will receive Ibuprofen, Diphenhydramine and Aluminium MgS mixture.

All patients will be instructed to apply the drug on the site of the ulcer 30-60 minutes before meals, 3 times daily. The ulcers will be assessed when the drug is applied for 3 days and the level of pain and irritation will be estimated by VAS (Visual Analogue Scale, a scaled ruler which the zero point displays the zone of lack of pain and the 10th point was considered as the zone of maximum pain). ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Supportive Care

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01293968
Study type Interventional
Source Qazvin University Of Medical Sciences
Contact
Status Completed
Phase Phase 2
Start date November 2010
Completion date February 2011
View Details
See also
  Status Clinical Trial Phase
Not yet recruiting NCT05542173 - Efficacy and Safety of BALI Association in the Treatment of Aphthous Ulcerations Phase 3
Completed NCT04884464 - Hyaluronic Acid in Counteracting Aphthous Stomatitis
Withdrawn NCT02535962 - Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Phase 2
Completed NCT04677062 - Safety, Galenic Acceptability and Efficacy of GV-328 Lozenges in Children With Oral Aphthosis N/A
Completed NCT02890524 - Tokushima Night Guard for Recurrent Aphthous Stomatitis N/A
Completed NCT02789605 - Effectiveness and Safety of Lactobacillus Rhamnosus Lcr35® in the Treatment of Recurrent Aphthous Stomatitis Phase 2
Recruiting NCT05772338 - Efficacy and Safety of BNP105 in the Treatment of Recurrent Aphthous Stomatitis N/A
Completed NCT00527306 - Prevention of Recurrent Aphthous Stomatitis Using Vitamins Phase 3
Completed NCT00001601 - Evaluation and Treatment of Oral Soft Tissue Diseases N/A
Completed NCT01210014 - Systemic Zinc Sulphate in Treatment of Recurrent Aphthous Ulcerations:A Doubleblind, Placebo Controled Study Phase 2