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Aphthous Stomatitis clinical trials

View clinical trials related to Aphthous Stomatitis.

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NCT ID: NCT05772338 Recruiting - Aphthous Stomatitis Clinical Trials

Efficacy and Safety of BNP105 in the Treatment of Recurrent Aphthous Stomatitis

Start date: January 22, 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of BNP105 in the treatment of recurrent aphthous stomatitis.

NCT ID: NCT05542173 Not yet recruiting - Aphthous Stomatitis Clinical Trials

Efficacy and Safety of BALI Association in the Treatment of Aphthous Ulcerations

Start date: September 2024
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of BALI association in the treatment of aphthous ulceration.

NCT ID: NCT04884464 Completed - Aphthous Stomatitis Clinical Trials

Hyaluronic Acid in Counteracting Aphthous Stomatitis

Start date: September 1, 2018
Phase:
Study type: Observational

Oral mucosal ulcers can determine a real worsening of the quality of life. Conventional therapy usually lasts not less than 2-3 weeks, and carries a high risk of serious side effects; furthermore, ulcers often recur. The use of hyaluronic acid applied as an adhesive gel over the lesions seems to have potential in terms of efficacy and the avoidance of side effects. Of course, hyaluronic acid-based formulations show different effects and tolerability. In this retrospective observational study, the results obtained using a hyaluronic-acid based medical device applied for 14 days to counteract ulcers in adults will be reported.

NCT ID: NCT04677062 Completed - Aphthous Stomatitis Clinical Trials

Safety, Galenic Acceptability and Efficacy of GV-328 Lozenges in Children With Oral Aphthosis

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

The aim of the study was to assess the safety, acceptability, and efficacy of product GV-328 for the treatment of childhood oral aphthous lesion.

NCT ID: NCT02890524 Completed - Aphthous Stomatitis Clinical Trials

Tokushima Night Guard for Recurrent Aphthous Stomatitis

Start date: July 2014
Phase: N/A
Study type: Interventional

The investigators will investigate whether the night guard can suppress the development of recurrent aphthous stomatitis (RAS). The investigators will record the patients' oral condition for 60 days before and after intervention with the night guard made of Ethylene-Vinyl Acetate copolymer (EVA). The patients' saliva will be analyzed for measurement of inflammatory cytokines or oxidative stress.

NCT ID: NCT02789605 Completed - Aphthous Stomatitis Clinical Trials

Effectiveness and Safety of Lactobacillus Rhamnosus Lcr35® in the Treatment of Recurrent Aphthous Stomatitis

Aphtose
Start date: January 4, 2018
Phase: Phase 2
Study type: Interventional

Recurrent aphthous stomatitis (RAS) is a frequent condition characterized by recurrent and painful oral ulcers with unknown pathophysiology. Recent studies suggest that a dysregulation of the oral microbiota may be implicated. Currently, therapies for RAS are limited by severe side effects or inconstant effectiveness. The aim of this study is to assess the effectiveness and safety of a probiotic, the Lactobacillus rhamnosus Lcr35® , in the treatment of RAS. A placebo-controlled, parallel study will be conducted in 40 subjects with RAS. Treatment consisted on the administration of the daily probiotics or placebo during 3 months.All patients will be then followed up for additional 3months without treatment. The main outcome measure will be the number of occurring aphtae.

NCT ID: NCT02535962 Withdrawn - Pharyngitis Clinical Trials

Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA)

PFAPA
Start date: October 2016
Phase: Phase 2
Study type: Interventional

The purpose of study is to see if adding probiotics to corticosteroid treatment for children with PFAPA could improve the health and daily of patients through reduction in febrile period frequency and length, along with concomitant reduction of associated symptoms. Current standard of care incorporates the administration of corticosteroids; however, while limiting the symptoms associated with PFAPA, corticosteroid use has been shown to increase the frequency at which these symptoms occur. Investigators hypothesize that administration of probiotics along with corticosteroids will work to decrease the frequency at which the febrile episodes occur. Additionally, probiotics may decrease the maximal fever experienced during these episodes, amount of corticosteroid needed to control the symptoms, average length of the episodes, and the number of patients who ultimately undergo tonsillectomy due to unsuccessful treatment with medication.

NCT ID: NCT01293968 Completed - Aphthous Stomatitis Clinical Trials

Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis

Start date: November 2010
Phase: Phase 2
Study type: Interventional

The intention of the study is to study the effects of Ibuprofen, Diphenhydramine and Aluminium MgS in decreasing the signs of recurrent aphthous stomatitis (RAS)

NCT ID: NCT01210014 Completed - Aphthous Stomatitis Clinical Trials

Systemic Zinc Sulphate in Treatment of Recurrent Aphthous Ulcerations:A Doubleblind, Placebo Controled Study

Start date: April 2008
Phase: Phase 2
Study type: Interventional

Recurrent aphthous stomatitis (RAS) is one of the most common of oral mucosa diseases that affects approximately 20% of the general population. Despite the fact that clinical, pathologic and therapeutic feature of the disease has been comprehensively studied, the pathophysiology of aphthous ulcers remains incompletely understood. Zinc is a potent catalyst of wound healing and zinc deficiency may be a common cause of delayed tissue repair. Use of zinc sulfate in promotion wound healing and preservation of epithelial integrity advocated its possible use in the treatment or prevention of recurrent oral ulcers. The purpose of the present study was to determine of systemic zinc sulphate in the treatment of recurrent aphthous stomatitis.

NCT ID: NCT00527306 Completed - Aphthous Stomatitis Clinical Trials

Prevention of Recurrent Aphthous Stomatitis Using Vitamins

Start date: December 2005
Phase: Phase 3
Study type: Interventional

The purpose of this research study is to find out if taking a multivitamin daily can affect the number of canker sores that people get and how long they last. Previous studies have shown that people who get canker sores are more likely to be deficient in one or more vitamins. It has also been found that correction of such vitamin deficiencies reduces the number and duration of canker sores. However, it is not known if taking a multivitamin daily will reduce the number and duration of canker sores.