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Hamburg AoRtic Valve cOhoRt — HARbOR  

Aortic Valve Stenosis Clinical Trial

Official title:
Clinical Cohort Study - Hamburg AoRtic Valve cOhoRt

Clinical Trial Summary

The primary aim of the study is to identify the optimal treatment modality for patients with aortic valve disease, incorporating the individual patient's risk profile and anticipated clinical outcomes. This includes the association of demographic factors, procedural data and biomarkers with clinical outcome in a prospective fashion.

Clinical Trial Description

Patients with severe aortic valve disease have a poor prognosis under medical therapy, making replacement of the failing valve the preferred option. In addition to surgical aortic valve replacement (SAVR), transcatheter aortic valve implantation (TAVI) has evolved as an alternative treatment option for patients at intermediate and high operative risk. Before expansion of TAVI to low-risk and younger patients can be recommended, several questions remain to be investigated, e.g. optimal patient selection, periprocedural complications and long-term durability. Therefore every patient with a relevant aortic valve disease (aortic stenosis, aortic regurgitation or degenerative aortic valve prosthesis) who meets the inclusion/exclusion criterias is planned to be involved in the study.

Predictors of outcome are yet to be defined in patients with aortic valve disease in order to improve risk prediction for the different treatment modalities (medical, SAVR, TAVI).

The primary aim of the study is to identify the optimal treatment modality for the individual patient, incorporating the individual patient's risk profile and anticipated clinical outcomes. This includes the association of demographic factors, procedural data and biomarkers with clinical outcome in a prospective fashion. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04227002
Study type Observational [Patient Registry]
Source Universitätsklinikum Hamburg-Eppendorf
Contact Moriz Seiffert, MD
Phone +49407410
Email m.seiffert@uke.de
Status Recruiting
Phase
Start date September 1, 2019
Completion date September 1, 2049
View Details
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