Aortic Valve Stenosis Clinical Trial
Official title:
Calcified Aortic Valve Stenosis (AVS). Markers of Fibrosis Using Cardiac Magnetic Resonance
Aortic valve stenosis (AVS) is the most frequent valvular disease. The severity of the obstruction of the left ventricle (LV) is essentially analyzed today by echocardiography Doppler, which assesses two key markers that are aortic valve pressure gradient and the aortic valve area. however these marker are a poor reflect of the clinical severity of AVS. The aim of the study is to validate new markers assessing cardiac fibrosis that might best or complementary markers.
To validate new markers assessing cardiac fibrosis three groups of subjects were studied in
controls subjects and patients with AVS in order to :
1. Analyze myocardial fibrosis markers in MRI, the degree of hypertrophy, remodeling and
wall shear stress in a control population and in three groups of subjects to RA
progressively increasing risk: asymptomatic subjects without symptomatic subjects LV
dysfunction, symptomatic patients with LV dysfunction. The factors favoring the
appearance of fibrosis observed in MRI will be analyzed on all subjects.
2. To validate these fibrosis markers estimated by MRI by histological analysis of
biopsies performed in patients undergoing aortic valve replacement.
3. Monitoring compliance with the distribution of markers of fibrosis and wall stress
estimated on Initial MRI are factors of aggravation or not improved function and / or
remodeling remote myocardial. Public hospitals in Paris
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Observational Model: Case Control, Time Perspective: Prospective
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