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NCT01939678 Clinical Trial

Characterization and Role of Mutations in Sodium-phosphate Cotransporters in Patients With Calcific Aortic Valve Disease

Aortic Valve Stenosis Clinical Trial

Official title:
Characterization and Role of Mutations in Sodium-phosphate Cotransporters in Patients With Calcific Aortic Valve Disease

Clinical Trial Details — Status: Terminated

Administrative data
NCT number NCT01939678
Other study ID # 2012-12
Secondary ID
Status Terminated
Phase
First received
Last updated
Start date September 2013
Est. completion date September 2019

Study information
Verified date September 2019
Source Region Örebro County
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this study is to investigate whether mutations in genes coding for Na/Pi-cotransporters are associated with aortic valve calcification. A patient population with premature aortic valve calcification treated with aortic valve replacement will be screened for mutations in these specific genes. Furthermore, aortic valve tissue received from the operations, will be examined for the presence of Na/Pi-cotransporters, and for molecular characterization of the transporters.

Recruitment information / eligibility
Status Terminated
Enrollment 3
Est. completion date September 2019
Est. primary completion date September 2019
Accepts healthy volunteers No
Gender All
Age group N/A to 65 Years
Eligibility Inclusion Criteria:

- Patients with aortic valve calcification that will be treated with an aortic valve replacement.

- Age = 65 years.

- Signed and dated informed consent.

Exclusion Criteria:

- Inability to provide informed consent

- Earlier radiation therapy of the thorax

- Severe renal disease (patients in treatment with dialysis)

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Sweden Department of Cardiology, Orebro University Hospital Orebro

Sponsors (1)
Lead Sponsor Collaborator
Region Örebro County

Country where clinical trial is conducted

Sweden, 

Outcome
Type Measure Description Time frame Safety issue
Primary Mutations in sodium-phosphate cotransporters in patients with calcific aortic valve disease Mutations in genes coding for Na/Pi-cotransporters At the time of aortic valve replacement
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