Aortic Valve Insufficiency Clinical Trial
Official title:
Multicenter, Randomized, Open-label Trial to Assess the Efficacy of Sacubitril/Valsartan vs. Amlodipine/Losartan on Left Ventricular Remodeling in Patients With Chronic Severe Aortic Regurgitation
The purpose of this study is to assess the efficacy of sacubitril-valsartan compared to the combination of ARB/CCB on left ventricular remodeling in patients with chronic aortic valve regurgitation.
After being informed consent about the study and potential risk, all patients giving written informed consent will undergo a 1 month screening period to determine eligibility for study entry. At week 0, patients who meet the eligibility requirements will be randomized in an open-label manner in a 1:1 ratio to sacubitril-valsartan or amlodipine/losartan. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04149600 -
Identification of Genetic Causes of Calcific Aortic Valve Disease
|
||
Enrolling by invitation |
NCT04035356 -
HAART Annuloplasty Device Valve Repair Registry
|
||
Unknown status |
NCT01201070 -
Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery
|
Phase 4 | |
Active, not recruiting |
NCT04281771 -
Assessment of Paravalvular Leak After TAVI by Hemodynamic Measurements and Cardiac MRI
|
N/A | |
Completed |
NCT03644784 -
Protocoled Quantitative Assessment of Aortic Regurgitation Using Videodensitometry in a Multicontinental Trial in Rotterdam, Montreal, Yamaguchi, Segeberg, Amsterdam.
|
||
Recruiting |
NCT02288871 -
Pilot Trial: Comparison of Flow Patterns
|
N/A | |
Completed |
NCT01651780 -
Open-label, Randomized Trial in Patients Undergoing TAVR to Determine Safety & Efficacy of Bivalirudin vs UFH
|
Phase 3 | |
Completed |
NCT01171625 -
Carpentier-Edwards PERIMOUNT Magna Ease Pericardial Bioprosthesis, Model 3300TFX
|
N/A | |
Terminated |
NCT00598598 -
Echocardiographic Assessment of Cardiovascular Changes in Long Term Space Flight
|
N/A | |
Recruiting |
NCT05295628 -
Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR
|
N/A | |
Recruiting |
NCT06034028 -
J-Valve TF Early Feasibility Study
|
N/A | |
Recruiting |
NCT06295068 -
Evaluation of ARi With OpSens SavvyWire
|
||
Completed |
NCT05742789 -
Effect of Anesthetics on Troponin I and С-reactive Protein
|
Phase 1 | |
Recruiting |
NCT05172973 -
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
|
N/A | |
Completed |
NCT00727181 -
An Observational, Prospective Evaluation of the Trifecta™ Valve
|
N/A | |
Active, not recruiting |
NCT04415047 -
The JenaValve ALIGN-AR Pivotal Trial
|
N/A | |
Not yet recruiting |
NCT02623907 -
China Valve Registry Study-1
|
N/A | |
Completed |
NCT00478803 -
Conservative Aortic Valve Surgery for Aortic Insufficiency and Aneurysms of the Aortic Root. CAVIAAR
|
Phase 3 | |
Completed |
NCT00475267 -
Aortic Valve Replacement With Trifecta(TM)
|
N/A | |
Completed |
NCT00001314 -
Investigation of Heart Function in Patients With Heart Valve Defects
|
N/A |