Clinical Trials Logo

Aortic Valve Disease clinical trials

View clinical trials related to Aortic Valve Disease.

Filter by:

NCT ID: NCT03894787 Completed - Clinical trials for Aortic Valve Disease

Ross for Valve Replacement in Adults - Registry

REVIVAL-Reg
Start date: June 3, 2019
Phase:
Study type: Observational [Patient Registry]

This registry follows patients undergoing two methods of aortic heart valve replacement in adults aged 18-60, the Ross procedure or conventional aortic valve replacement using a biologic or mechanical heart valve. The Ross procedure replaces a patient's diseased aortic valve with his/her own pulmonary valve and uses a donor valve in the pulmonary position which receives less stress than the aortic valve. Mechanical valves tend to form blood clots so they need long-term blood thinners that increase risk of bleeding and lower quality of life. Animal tissue valves reduce clotting and bleeding risks but wear out sooner and shorten patient life-span. The REVIVAL Registry will run in parallel with the REVIVAL randomized trial.

NCT ID: NCT03818126 Completed - Clinical trials for Aortic Valve Disease

The Del Nido Versus Cold Blood Cardioplegia in Aortic Valve Replacement

Start date: July 1, 2016
Phase: N/A
Study type: Interventional

A group of 150 patients undergoing aortic valve replacement procedure will be randomized either into del Nido cardioprotection protocol (75 participants) or into the cold blood cardioplegia protocol (75 participants). The intraoperative and perioperative outcomes of using each solution will be presented and compared (see the endpoints).

NCT ID: NCT03807921 Completed - Clinical trials for Aortic Valve Stenosis

Anticoagulation for Aortic Bioprosthesis (ANTIPRO)

Start date: January 1, 2019
Phase: Phase 4
Study type: Interventional

This study evaluates the clinical and hemodynamic outcome in patients after aortic valve replacement. Half of the patients will receive warfarin + aspirin and the other half will receive only aspirin. The investigators will focus mainly on early bioprosthesis degeneration.

NCT ID: NCT03798782 Completed - Clinical trials for Aortic Valve Disease

Ross for Valve Replacement in AduLts Trial

REVIVAL
Start date: April 29, 2019
Phase: N/A
Study type: Interventional

This study evaluates two methods of aortic heart valve replacement in adults aged 18-60, the Ross procedure versus conventional aortic valve replacement using a biologic or mechanical heart valve. The Ross procedure replaces a patient's diseased aortic valve with his/her own pulmonary valve and uses a donor valve in the pulmonary position which receives less stress than the aortic valve. Mechanical valves tend to form blood clots so they need long-term blood thinners that increase risk of bleeding and lower quality of life. Animal tissue valves reduce clotting and bleeding risks but wear out sooner and shorten patient life-span.

NCT ID: NCT03796442 Completed - Clinical trials for Aortic Valve Disease

Comparison of Two Pericardial Bioprostheses in AVR

Start date: January 23, 2019
Phase: N/A
Study type: Interventional

The purpose of the study is to compare early and 1-year hemodynamic performance and clinical outcomes after aortic valve replacement using two pericardial bioprosthesis, Avalus and Carpentier Edwards Perimount Magna Ease.

NCT ID: NCT03677804 Completed - Clinical trials for Aortic Valve Disease

Aortic Valve Reconstruction Using Autologous Pericardium: Single Center Experience With the Ozaki Technique

Start date: August 2, 2017
Phase:
Study type: Observational

The aim of this study is to analyse the short-term results of the first patients undergoing the OZAKI procedure (Aortic valve reconstruction using autologous pericardial tissue) at the department of cardiac surgery/ University Hospital Basel/ Switzerland.

NCT ID: NCT03239262 Completed - Clinical trials for Coronary Artery Disease

Left Atrial Cryoablation Enhanced by Ganglionated Plexi Ablation in the Treatment of Atrial Fibrillation

Start date: July 1, 2012
Phase: N/A
Study type: Interventional

The aim of our study was to investigate, whether enhancement of left atrial cryoablation by ablation of the autonomic nervous system of left atrium leads to influencing the outcomes of surgical treatment of atrial fibrillation in patients with structural heart disease undergoing open-heart surgery.

NCT ID: NCT03223558 Completed - Clinical trials for Coronary Artery Disease

Early Initiation of Post Sternotomy CArdiac Rehabilitation

SCAR
Start date: July 10, 2017
Phase: N/A
Study type: Interventional

The main objective of this trial is to investigate the effects of starting exercise rehabilitation earlier than current practice after coronary artery bypass graft(CABG) or Aortic/Mitral valve replacement (VR) surgery.

NCT ID: NCT03135496 Completed - Clinical trials for Endothelial Dysfunction

Evaluation of Endothelial Dysfunction During Aortic Valvular Replacement by Bioprosthesis With and Without Extracorporeal Circulation

DYVA2
Start date: January 5, 2017
Phase:
Study type: Observational

Patients with aortic stenosis present many risk factors for endothelial dysfunction (arterial hypertension, arteriosclerosis, dyslipidemia, chronic renal insufficiency, etc.). It is likely that a significant number of patients suffer from pre-existing endothelial dysfunction that can be evaluated by a molecular approach. To date, the replacement of the aortic valve can be performed by surgery with extracorporeal circulation (CEC) or percutaneous (Transcatheter Aortic Valve ImplantationTAVI) without CEC. Two recent studies have demonstrated a sustained improvement in endothelial function with TAVI. On the contrary, studies have demonstrated that post-operative complications (coagulopathy, capillary leak syndrome, acute vasoplastic disorder and acute renal failure) after surgery with extracorporeal circulation (CEC) could be the result of the interaction between pre-existing endothelial dysfunction And the "operative" aggression associated with the CEC. Thus, patients with preexisting involvement of endothelial function would develop vascular dysfunction after valvular replacement due to "endothelial activation" related to CEC. This phenomenon would not exist in TAVI, and would explain the absence of so-called vascular dysfunction complications (Systemic inflammatory response syndrome, vasoplastic syndrome, disseminated intravascular coagulation).

NCT ID: NCT03130491 Completed - Clinical trials for Aortic Valve Disease

European Study Evaluating the EMBLOK Embolic Protection System During TAVR

Start date: March 8, 2017
Phase: N/A
Study type: Interventional

The primary objective is to evaluate the performance and the treatment effect of the use of the Emblok embolic protection system use during transcatheter aortic valve replacement with respect to procedure-related cerebral embolic burden as determined by DW-MRI.