Changes in Elastic Properties of Descending Thoracic Aorta After Ascending Aorta Replacement

Aortic Surgery Clinical Trial

Official title:

Impact of Ascending Aorta Replacement by Graft on Elastic Properties of Descending Thoracic Aorta Evaluated by Cardiac Magnetic Resonance Imaging

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03817008
• Other study ID #: MORGANT 2019
• Status: Completed
• Start date: September 1, 2014
• Est. completion date: January 17, 2019

Study information

• Verified date: January 2019
• Source: Centre Hospitalier La Chartreuse
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of our study was to evaluate the impact of aortic root replacement by a graft on the elastic properties of the descending thoracic aorta using cardiac Magnetic Resonance Imaging (MRI) and automatic post-processing.

Nineteen patients were operated on an aortic root aneurysm and a cardiac MRI allowing aortic compliance measurement was performed before and after surgery. Images were acquired with a 1.5 T MRI with only one additional sequence to a conventional aortic MRI protocol.

Description:

Observational and retrospective trial on medical data only. The patients are operated of planned aortic root aneurysm without additional intervention.

The pre and postoperative cardiac MRI are planned in standard of care.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 19
• Est. completion date: January 17, 2019
• Est. primary completion date: January 17, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 99 Years

Eligibility

Inclusion Criteria:

• > 18 years

• Elective patient

• Ascending aorta replacement with graft

Exclusion Criteria:

• Prior cardiac surgery

• Contraindication to performing cardiac MRI

Related Conditions & MeSH terms

• Aortic Surgery

Intervention

Procedure:
• Ascending aorta replacement with graft
Patient with planned Ascending aorta replacement with graft

Locations

Country	Name	City	State
n/a

Sponsors (6)

Lead Sponsor	Collaborator
Centre Hospitalier La Chartreuse	BOUCHOT Olivier, JAZAYERI Aline, JAZAYERI Saed, MALAPERT Ghislain, PETROSYAN Andreanik

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Aortic compliance of descending aorta (mm2/mmHg)	Aortic elastic properties of the descending aorta before and after aortic root replacement using cardiac MRI.; Aortic compliance is a local measurement of elastic properties which is obtained with cardiac MRI images by computer processing.	post-operative cardiac MRI performing between 12 and 24 months
Secondary	Aortic compliance of ascending aorta (mm2/mmHg)	Aortic elastic properties of the ascending aorta before and after aortic root replacement using cardiac MRI.; Aortic compliance is a local measurement of elastic properties which is obtained with cardiac MRI images by computer processing.	post-operative cardiac MRI performing between 12 and 24 months