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NCT06065306 Clinical Trial

Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department

Aortic Dissection Clinical Trial

— ADD-ED  

Official title:
Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department: the Aggrecan, Desmosine, D-dimer-Emergency Department (ADD-ED) Study

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT06065306
Other study ID # CREC 2022.631
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date June 18, 2023
Est. completion date December 31, 2025

Study information
Verified date April 2024
Source Chinese University of Hong Kong
Contact Colin A Graham
Phone +85235051033
Email cagraham@cuhk.edu.hk
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

The goal of this observational study is to determine the utility of desmosine, D-dimer and aggrecan as early diagnostic biomarkers in aortic dissection. The main questions it aims to answer are: - To investigate the plasma levels of selected biomarkers in ED patients with confirmed aortic dissection - To study the diagnostic performance of plasma levels of selected biomarkers for aortic dissection - To study the association between plasma levels of selected biomarkers and clinical outcomes

Recruitment information / eligibility
Status Recruiting
Enrollment 47
Est. completion date December 31, 2025
Est. primary completion date December 31, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Age = 18 years - Presentation to the ED with first 24 hours of symptoms suggesting AD, including chest pain, upper back pain, syncope of unknown cause, symptoms of any acute perfusion deficit - Confirmed AD - the diagnosis of AD adjudicated by an independent expert panel at hospital discharge or death, whichever comes first - The expert panel will consist of (1) a specialist in Emergency Medicine and (2) a specialist in Cardiology and (3) a specialist in Cardiothoracic Surgery. Exclusion Criteria: - Age <18 years old - Pregnancy - Surgery or stenting performed before recruitment

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Hong Kong Prince of Wales Hospital Sha Tin NT

Sponsors (1)
Lead Sponsor Collaborator
Chinese University of Hong Kong

Country where clinical trial is conducted

Hong Kong, 

Outcome
Type Measure Description Time frame Safety issue
Primary Serum levels of D-Dimer, Aggrecan and Desmosine Biomarkers :Serum levels of D-Dimer, Aggrecan and Desmosine will be compared in patients with confirmed AD versus age and sex matched healthy controls Blood samples taken preoperatively
See also
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