Angiotensin II Pathway and Postoperative Hypoxemia

Aortic Dissection Clinical Trial

Official title:

The Mechanism Research of Angiotensin II Pathway and Postoperative Hypoxemia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05055570
• Other study ID #: 2021107X
• Status: Completed
• Start date: August 12, 2021
• Est. completion date: June 1, 2022

Study information

• Verified date: April 2023
• Source: Beijing Anzhen Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Acute type A aortic dissection is often accompanied by postoperative hypoxemia, the cause of which is not fully understood. Angiotensin II is an important component of the renin-angiotensin system (RAS), which has been suggested to be involved in the development of aortic dissection and pulmonary inflammation.The purpose of this study was to investigate the role and mechanism of angiotensin II pathway in postoperative hypoxemia after acute type A aortic dissection, and to provide reference for clinical application

Recruitment information / eligibility

• Status: Completed
• Enrollment: 88
• Est. completion date: June 1, 2022
• Est. primary completion date: June 1, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• patients undergoing surgery for acute type A aortic dissection

• age between 18 to 80

Exclusion Criteria:

• perioperative severe cardiac insufficiency

• rejection of consent

Related Conditions & MeSH terms

• Aortic Dissection
• Hypoxia

Intervention

Other:
• No intervention
No intervention

Locations

Country	Name	City	State
China	Anzhen hospital, Beijing	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Beijing Anzhen Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The Difference Concentrations of ANG II in Serum Between Patients With and Without Postoperative Hypoxemia.	Blood samples were taken within 24 hours after operation to detect the contents of ANG II in serum. Postoperative hypoxemia is defined by the oxygenation index (OI), which is the ratio of arterial partial pressure of oxygen to fraction inspired oxygen (PaO2 / FiO2), of less than or equal to 200 for two consecutive times within the first 24 h after operation	Within 24 hours after surgery
Secondary	The Risk Factors for Postoperative Hypoxemia in Stanford Type A Acute Aortic Dissection Patients.	Basic characteristics, intraoperative details, biochemical parameters and outcome results were obtained, and blood was collected within 24 hours after surgery for the measurement of ANG II, sACE2 and mir-145 concentrations. Univariate analysis was first performed to identify the potential risk factors for postoperative hypoxemia. Multivariate logistic regression analysis was performed for factors with P < 0.05 or that were considered clinically important.	up to 60 days
Secondary	Duration of Stay in the Intensive Care Unit	Duration of Stay in the intensive care unit after surgery	up to 60 days