Aortic Aneurysm Clinical Trial
Official title:
Influence of Short AV Delay Pacing on Matrix Metalloproteinase Lives
Verified date | December 2018 |
Source | Istanbul University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
As potential biomarkers of pressure-related aortic damage, matrix metalloproteinases (MMP) have been implicated in the pathogenesis of aortic aneurysm because of the important role they play in connective tissue homeostasis. In particular, a significant reduction in initially elevated serum MMP - 9 concentrations, compared with healthy controls, demonstrated after the aortic repair in patients with abdominal aortic aneurysm implies MMPs pivotal role in aortic aneurysms. Besides, due to an active degradation and repair processes taking place in the vascular wall governed by the balance between MMP enzymes and their inhibitors, MMP - 9, expression of which is predominantly associated with disruption of aortic elastic fibers, can also be detected in the serum of healthy subjects. Indeed, mechanical stress-induced upregulation of genes and their products stimulate MMP expression in the vascular wall, which is responsible for extracellular matrix degradation. Herein, it was hypothesized that reducing the acceleration rate of aortic pressure (aortic peak dP/dt) may decrease the mechanical stretch on the aortic wall which, may in turn, reduce the expression and serum levels of MMP-9.
Status | Completed |
Enrollment | 20 |
Est. completion date | November 15, 2018 |
Est. primary completion date | November 15, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Normal LV systolic function (EF>50%), - Healthy conduction systems - Noncritical coronary stenoses or normal coronary arteries - Ventricular pacing rate <10% in the last 6 months detected at the interrogation of the pacemakers Exclusion Criteria: - Intra-ventricular conduction abnormalities (baseline QRS >100 msec.), - Mild to moderate aortic or mitral valve disease - Presence of atrial fibrillation - LV systolic dysfunction |
Country | Name | City | State |
---|---|---|---|
Turkey | Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology | Istanbul |
Lead Sponsor | Collaborator |
---|---|
Istanbul University |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in MMP - 9 serum concentration from baseline to at the end of 3 weeks follow-up | MMP-9 serum concentration will be measured before and after short AV delay (wide QRS) pacing. Change in MMP-9 levels will be measured. | 3 weeks |
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