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NCT01918982 Clinical Trial

Circulating Endothelial Progenitor Cells and Aortic Aneurysm

Aortic Aneurysm Clinical Trial

— ANOPEC3  

Official title:
Interest of Circulating Endothelial Progenitor Cells CD34+144+CD14- and CD34+VEGF-R2+CD14- in the Follow-up of Aortic Aneurysm

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT01918982
Other study ID # 147/362
Secondary ID
Status Not yet recruiting
Phase N/A
First received August 6, 2013
Last updated August 7, 2013
Start date October 2013
Est. completion date May 2016

Study information
Verified date August 2013
Source Hopital Jean Minjoz
Contact Sidney Chocron
Phone +33381533121
Email sidney.chocron@univ-fcomte.fr
Is FDA regulated No
Health authority France: Health Agency
Study type Observational

Clinical Trial Summary

We aimed to see if aortic aneurysms could be followed-up by circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- blood level.

Description:

Circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- have been shown to be inversely correlated to aortic aneurysm size. We aimed to see if aortic aneurysms could be followed-up by circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- blood level. 40 patients followed for known aortic aneurysm >30mm and <50mm will be followed up every 6 months during 2 years. Each 6 months they will have a consultation by their physiologist with an echo or a CT-scan. At the same time, a 10ML blood sample will be taken to assess the circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- blood level.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 40
Est. completion date May 2016
Est. primary completion date February 2016
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 85 Years
Eligibility Inclusion Criteria:

- Aortic aneurysm size >30mm and > 50mm

Exclusion Criteria:

- Infectious disease

- Inflammatory disease

- Liver insuffisency

- Cancer evolutive

- Pregnant women

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Hopital Jean Minjoz

References & Publications (1)

Parietti E, Pallandre JR, Deschaseaux F, Aupècle B, Durst C, Kantelip JP, Chocron S, Davani S. Presence of circulating endothelial progenitor cells and levels of stromal-derived factor-1a are associated with ascending aorta aneurysm size. Eur J Cardiothorac Surg. 2011 Jul;40(1):e6-12. doi: 10.1016/j.ejcts.2011.02.065. Epub 2011 Apr 9. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- blood concentration Patients are followed for 2 years 2 years No
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