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NCT01918969 Clinical Trial

Reference Values of Circulating Endothelial Progenitor Cells

Aortic Aneurysm Clinical Trial

— ANOPEC2  

Official title:
Determination of Reference Values of Circulating Endothelial Progenitor Cells CD34+144+CD14- and CD34+VEGF-R2+CD14- in a Blood Donnor Population

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT01918969
Other study ID # 13/408
Secondary ID
Status Not yet recruiting
Phase N/A
First received August 6, 2013
Last updated August 7, 2013
Start date October 2013
Est. completion date March 2014

Study information
Verified date August 2013
Source Hopital Jean Minjoz
Contact Sidney Chocron, MD, PhD
Phone +33381533121
Email sidney.chocron@univ-fcomte.fr
Is FDA regulated No
Health authority France: Health agency
Study type Observational

Clinical Trial Summary

Circulating endothelial progenitor cells CD34+144+CD14- et CD34+VEGF-R2+CD14- have been shown to be inversely correlated to aortic aneurysm size. However reference values have not yet been determined. This study is aimed to determine reference values of CD34+144+CD14- et CD34+VEGF-R2+CD14- in healthy men and women blood donors.

Description:

At the time of blood donation, 10mL of blood will be used to calculate the concentration of circulating endothelial progenitor cells CD34+144+CD14- et CD34+VEGF-R2+CD14- , and the ratio of circulating endothelial progenitor cells CD34+144+CD14- et CD34+VEGF-R2+CD14- / all circulating endothelial progenitor cells in order to determine reference values.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 120
Est. completion date March 2014
Est. primary completion date January 2014
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

- Blood donors

Exclusion Criteria:

- age over 65

- Arterial hypertension (treated or not)

- Vascular disease

- smoker or former smoker who stopped smoking for less than a year

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
France CHU Besançon Besançon

Sponsors (1)
Lead Sponsor Collaborator
Hopital Jean Minjoz

Country where clinical trial is conducted

France, 

References & Publications (1)

Parietti E, Pallandre JR, Deschaseaux F, Aupècle B, Durst C, Kantelip JP, Chocron S, Davani S. Presence of circulating endothelial progenitor cells and levels of stromal-derived factor-1a are associated with ascending aorta aneurysm size. Eur J Cardiothorac Surg. 2011 Jul;40(1):e6-12. doi: 10.1016/j.ejcts.2011.02.065. Epub 2011 Apr 9. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Concentration of circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- 3 months No
Secondary Ratio of circulating endothelial progenitor cells CD34+144+CD14- et CD34+VEGF-R2+CD14- / all circulating endothelial progenitor cells 3 months No
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