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Pre-emptive Pregabalin on Attenuating Maternal Anxiety And Stress Response To Intubation During Caesarean Section

Sedation Clinical Trial

Official title:
The Effects Of Pre-emptive Single Oral Dose Pregabalin on Attenuating Maternal Anxiety And Stress Response To Intubation During Caesarean Section

Clinical Trial Summary

There is exaggerated neuroendocrine stress response to laryngoscopy and endotracheal intubation during the Induction to anesthesia-delivery (I-D) period under light anesthesia. Mechanical stimulation of laryngeal proprioceptors elicits increased secretion of cortisol and catecholamine with subsequent elevation of blood pressure from 40 to 50 % and heart rate up to 20 % during direct laryngoscopy and endotracheal intubation

Clinical Trial Description

The sample size was calculated using OPEN EPI program assuming that the mean visual analogue scale anxiety score was 49.3±14.1 among oral pregabalin group and was 58.6± 14.4 among Placebo group (8) so at power of study 80% confidence interval 95%, the sample size was calculated to be 74 cases (37in each group ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04622202
Study type Interventional
Source Zagazig University
Contact Sara Abdel Naby, M.D
Phone 01096017090
Email sara.abdelnaby.ali@gmail.com
Status Recruiting
Phase Phase 1/Phase 2
Start date November 15, 2020
Completion date March 1, 2021
View Details
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