Anxiety Depression Clinical Trial
Official title:
Real-life Assessment of Aripiprazole Long-acting Injection (Abilify Maintena) Combined With Brexpiprazole (Rexulti) in Schizophrenia: a Naturalistic Non-interventional Prospective Follow-up Study
MainRexult study aims to carefully evaluate a cohort of patients with schizophrenia and related disorder prescribed with the combination therapy with Abilify Maintena and Rexulti on its efficacy and tolerability in a real-life clinical setting.
Currently, there is no recommendation on next-step treatment strategy if the patients remain suffering from residual symptoms, have incomplete remission, or have acute exacerbation of schizophrenia whilst receiving aripiprazole long acting injection at its recommended (maximum) dose, except to switch to other second generation antipsychotics (SGA) or to clozapine if they are in their treatment-resistant course. Such practice may incur risks of full relapse and/or unnecessary side effects to the patients, in particularly to those already showed insufficient treatment response, intolerability to side effects, or non-adherence to other antipsychotics before. On the contrary, adding another SGAs to this special cohort appears to be rational. Especially, brexpiprazole might be an ideal choice for its serotonin-dopamine activity modulator property to achieve better symptom control, and at the same time retaining the benefits from the lower incidence of side effects than other SGAs. Cases reports on combination therapy with aripiprazole (oral or LAI) with brexpiprazole had demonstrated initial favorable outcomes, albeit lacking empirical evidence from randomized controlled trial or longer term follow-up study. Therefore, the current MainRexult study aims to carefully evaluate a cohort of patients with schizophrenia and related disorders prescribed with the combination therapy with Abilify Maintena and Rexulti on its efficacy and tolerability in an non-interventional, naturalistic real-life clinical setting. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06065787 -
NeuroGlove Anxiety and Depression Study
|
N/A | |
| Completed |
NCT03981406 -
Palliative Care and Quality of Life in Idiopathic Pulmonary Fibrosis
|
N/A | |
| Not yet recruiting |
NCT05911412 -
Development of the Neuroimaging Biomarker-based Prediction Model of Anxiety-related Disorders: Effect of Mindfulness-based Cognitive Therapy Using Neuroscience on the Brain
|
N/A | |
| Not yet recruiting |
NCT05860257 -
Transforming Adolescent Mental Health Through Accessible, Scalable, Technology-supported Small-group Instruction
|
N/A | |
| Recruiting |
NCT05390034 -
Improving Emotion Regulation Flexibility: Testing the Efficacy of an Emotion Regulation Program in College Students
|
N/A | |
| Completed |
NCT04307563 -
Effects of Mindfulness Training on Burnout and Mood in Hospital Employees
|
N/A | |
| Recruiting |
NCT06190184 -
Viome Precision Nutritional Programs to Improve Clinical Outcomes for Mental Health Conditions
|
N/A | |
| Enrolling by invitation |
NCT05529381 -
Anxiety and Depressive Symptoms in Placenta Previa / Accreta
|
||
| Active, not recruiting |
NCT03090867 -
Participation of Relative or Surrogate in the Patient's Care in Reanimation
|
N/A | |
| Completed |
NCT04189354 -
Study of the Synergistic Effects of Biofeedback and Transcranial Electrical Stimulation in Anxio-depressive Disorders
|
N/A | |
| Completed |
NCT05150574 -
HRV and Coaching Preparation Phase Study
|
Phase 1 | |
| Completed |
NCT03889301 -
¡Yo no Estoy Loc@! Improving Treatment Engagement for Latinos Using an E-E Video
|
N/A | |
| Completed |
NCT04498442 -
A Study on Prevalence, Protection and Recovery From COVID-19 in Seasoned Yoga Practitioners in Comparison to Age and Gender Matched Controls
|
N/A | |
| Not yet recruiting |
NCT03190291 -
A Stepped-Care Telehealth Approach To Treat Distress In Rural Cancer Survivors
|
N/A | |
| Recruiting |
NCT04406181 -
Psychological Well-being of Patients Awaiting for Cardiac Surgery During the COVID-19 Pandemic
|
N/A | |
| Completed |
NCT05871580 -
Effect to the Photobiomodulation in the Burning Mouth Syndrome
|
N/A | |
| Completed |
NCT04299256 -
Benson Relaxation Technique Combined With Music Therapy for Fatigue, Anxiety, and Depression in Hemodialysis Patients
|
N/A | |
| Recruiting |
NCT05570812 -
Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV
|
Phase 2 | |
| Completed |
NCT04572659 -
Psychosocial Intervention in Assisted Reproduction Treatments
|
N/A | |
| Not yet recruiting |
NCT06035731 -
Evaluation of the Medical Service by Socio-aesthetics in Oncology
|
N/A |