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Antispastic Therapy clinical trials

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NCT ID: NCT04310995 Completed - Clinical trials for Coronary Artery Bypass Graft

Different Anti-Spastic Therapy Strategies After CABG Using Radial Artery Grafts

ASRAB-Pilot
Start date: June 2, 2020
Phase: Phase 4
Study type: Interventional

The Pilot study will be a single-center, randomized, open-label, active-controlled trial. After CABG surgery using Radial Artery Grafts (RA-CABG) and signing the informed consent, all patients will be screened according to the inclusion and exclusion criteria. Estimated 150 patients will be enrolled and randomized by ratio 1:1:1 to receive either Nicorandil (5mg tid po) or Diltiazem (180mg qd po) or Isosorbide Mononitrate (50mg qd po). Follow-up visits will be conducted at Week 1, 4, 12, and 24 after surgery. The last evaluation of study endpoints and other adverse events will be at Week 24. The pilot study is designed to explore the angiography outcomes of grafts and cardiovascular outcomes of patients, as well as safety outcomes among different anti-spastic regimens after RA-CABG.