Aggression Clinical Trial
Official title:
Omega-3 Supplementation and Behavior Problems in Children and Adolescents
The objectives of this project are as follows:
1. To assess whether omega-3 dietary supplementation for six months can reduce
externalizing behavior problems (antisocial and aggressive behavior) in schoolchildren
aged 8 to 18, both at the end of treatment and six months post-treatment
2. To assess whether omega-3 supplementation is more effective in children with more
psychopathic-like traits.
Externalizing behavior problems (aggressive and antisocial behaviors) are widely recognized
as predisposing to significant mental health problems and violence among adolescents in
secondary schools. These in turn result in enormous economic and social costs to schools as
well as to society. These costs include mental illness, crime, and violence. Similarly,
violence is widely recognized as a major public health problem which has also largely defied
successful intervention and prevention. Because an increasing body of research is documenting
health and neurobiological risk factors for aggression and violence, part of this prevention
failure may be due to intervention efforts ignoring biological contributory factors which
include impaired neurocognitive and psychophysiological functioning. One benign biological
intervention that may help attenuate behavior problems in children consists of omega-3
supplementation of the diet, a long-chain fatty acid critical for brain structure and
function.
The overarching aim of this study is to assess whether omega-3 supplementation can reduce the
base level of externalizing behavior problems in children and adolescents. A secondary but
important aim is to assess whether any behavioral improvement may be greater in more
psychopathic children. The specific aims are as follows:
1. To assess the effectiveness of omega-3 dietary supplementation in reducing externalizing
behaviors in adolescents.
2. To assess whether omega-3 supplementation leads to greater improvement in children with
psychopathic-like traits.
Hypotheses will be tested in a placebo-controlled, double-blind, randomized trial involving 8
to18 year-old adolescents drawn from primary and secondary schools in Hong Kong. Omega-3
supplementation will be in the form of a Norwegian fruit juice drink. 300 adolescents will be
randomly assigned into: (1) omega-3 supplemented drink, (2) placebo drink, (3)
treatment-as-usual controls. Behavioral measures will be assessed at baseline (0 months), end
of treatment (6 months), and 6 months post-treatment (12 months).
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