Antimicrobial Resistance Clinical Trial
Official title:
Impact of Reducing Colistin Use on Colistin Resistance in Humans and Poultry in Indonesia
Colistin (polymyxin E) is considered a last resort antimicrobial for treatment of infections with multidrug- resistant bacteria, classified by WHO as 'highest prioritized, critically important for human medicine'. WHO suggests to ban or highly restrict its use in animals. In Indonesia, colistin resistance in human Escherichia coli isolates is poorly characterized as it requires specific non-routine tests. Presence of colistin resistance in E. coli in poultry resulted in a ban for livestock in Indonesia in 2020. However, colistin is still suspected to be routinely used in humans in multiple settings but the reasons for these practices are poorly understood. The ban on colistin use in livestock offers a unique opportunity to assess the impact of this intervention on colistin resistance in humans and animals, and how a One Health perspective can strengthen this intervention. This project aims to: i) determine phenotypic and genotypic colistin resistance in E. coli from humans and poultry in Indonesia; ii) assess the impact of the colistin ban on resistance in E. coli in animals and humans; iii) estimate the transmission of colistin resistance between animals and humans; iv) study colistin use and perceptions at the community level; and v) expand the initial colistin ban in the animal production sector into an integrative multi-sectorial One Health intervention, which will be designed and implemented using a community participatory approach. This project will provide a strong scientific basis to AMR policies in Indonesia, with great significance across Southeast Asia.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04182230 -
UROGEN WELL D-ONE : Evaluation of a Novel Diagnostic for Sexually Transmitted Bacterial Infections
|
||
| Recruiting |
NCT02814877 -
Efficacy and Cost-effectiveness of Hospital Antimicrobial Stewardship Programs
|
N/A | |
| Completed |
NCT03388944 -
PCT Guided Stopping of Antibiotic Therapy in Children With Sepsis
|
N/A | |
| Completed |
NCT05734391 -
Surveillance of Healthcare-associated Infections & Antimicrobial Resistance
|
||
| Completed |
NCT03794479 -
Intestinal Microbiota and Antimicrobial Resistance in Hong Kong Residents After Travel
|
||
| Recruiting |
NCT05942157 -
Therapeutic Drug Monitoring in Patients With Difficult-to-Treat Gram-Negative Bacterial Infections
|
N/A | |
| Recruiting |
NCT05296837 -
Ocular Rosacea Biome Study
|
Phase 4 | |
| Completed |
NCT05451836 -
N-of-1 Trials of Interventions to Improve Decision-making for Antibiotic Use
|
N/A | |
| Not yet recruiting |
NCT06436690 -
Optimizing Antibiotics Prescription
|
N/A | |
| Completed |
NCT05445414 -
A Mobile App Serious Game to Increase Awareness of Antibiotic Use in the Community
|
N/A | |
| Not yet recruiting |
NCT05089760 -
Microbiology, Antimicrobial Resistance and Outcomes of Neonatal Sepsis in China
|
||
| Recruiting |
NCT04388293 -
Using Antibiotics Wisely - An Antimicrobial Stewardship Program
|
||
| Completed |
NCT05285657 -
Algorithm Using a Rapid Diagnostic Test for the Management of Childhood Febrile Diseases.
|
N/A | |
| Completed |
NCT03479710 -
Fecal Microbiota Transplantation for CRE/VRE
|
Phase 2 | |
| Recruiting |
NCT06358872 -
Azithromycin for Child Survival in Niger II
|
Phase 4 | |
| Not yet recruiting |
NCT06305455 -
Resistance Profile of Escherichia Coli in Infections of Community Origin: The Importance of Antimicrobial Stewardship
|
||
| Not yet recruiting |
NCT06356285 -
Testing New Ways to Name Antimicrobial Resistance
|
N/A |